AMOTL2 (angiomotin like 2)

2014-04-01  

Identity

HGNC
AMOTL2
LOCATION
3q22.2
LOCUSID
51421
ALIAS
LCCP
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 51421
MIM: 614658
HGNC: 17812
Ensembl: ENSG00000114019

Variants:

dbSNP: 51421
ClinVar: 51421
TCGA: ENSG00000114019
COSMIC: AMOTL2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000114019ENST00000249883Q9Y2J4
ENSG00000114019ENST00000422605Q9Y2J4
ENSG00000114019ENST00000502491D6RFG0
ENSG00000114019ENST00000504234D6RF61
ENSG00000114019ENST00000505596D6RJA4
ENSG00000114019ENST00000506107D6RBK2
ENSG00000114019ENST00000510560D6RCL7
ENSG00000114019ENST00000513145Q9Y2J4
ENSG00000114019ENST00000514516Q9Y2J4
ENSG00000114019ENST00000515172D6RIC7

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Tight junctionKEGGko04530
Tight junctionKEGGhsa04530
Signal TransductionREACTOMER-HSA-162582
Signaling by HippoREACTOMER-HSA-2028269

References

Pubmed IDYearTitleCitations
218321542011Angiomotin family proteins are novel activators of the LATS2 kinase tumor suppressor.85
242259522013Actin-binding and cell proliferation activities of angiomotin family members are regulated by Hippo pathway-mediated phosphorylation.41
259981282015Phosphorylation of the Hippo Pathway Component AMOTL2 by the mTORC2 Kinase Promotes YAP Signaling, Resulting in Enhanced Glioblastoma Growth and Invasiveness.25
219374272011Angiomotin-like2 gene (amotl2) is required for migration and proliferation of endothelial cells during angiogenesis.21
235250082013Amotl2 interacts with LL5β, localizes to podosomes and regulates postsynaptic differentiation in muscle.18
250809762014AmotL2 disrupts apical-basal cell polarity and promotes tumour invasion.17
265985512016Role of Angiomotin-like 2 mono-ubiquitination on YAP inhibition.16
240032522013Angiomotin'g YAP into the nucleus for cell proliferation and cancer development.13
239112992013AMOTL2 interaction with TAZ causes the inhibition of surfactant proteins expression in lung cells.5
283684152017Angiomotin-like 2 interacts with and negatively regulates AKT.2

Citation

Dessen P

AMOTL2 (angiomotin like 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-04-01

Online version: http://atlasgeneticsoncology.org/gene/53853/amotl2