ANKRD2 (ankyrin repeat domain 2)

2007-02-01  

Identity

HGNC
LOCATION
10q24.2
LOCUSID
ALIAS
ARPP

Other Information

Locus ID:

NCBI: 26287
MIM: 610734
HGNC: 495
Ensembl: ENSG00000165887

Variants:

dbSNP: 26287
ClinVar: 26287
TCGA: ENSG00000165887
COSMIC: ANKRD2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000165887ENST00000298808Q9GZV1
ENSG00000165887ENST00000307518Q9GZV1
ENSG00000165887ENST00000370655A0A0A0MRN9
ENSG00000165887ENST00000455090Q5T457

Expression (GTEx)

0
50
100
150
200
250
300
350
400
450

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
163854512006A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.69
151360352004The Ankrd2 protein, a link between the sarcomere and the nucleus in skeletal muscle.42
221856182011Muscle ankyrin repeat proteins: their role in striated muscle function in health and disease.29
217376862011Ankrd2/ARPP is a novel Akt2 specific substrate and regulates myogenic differentiation upon cellular exposure to H(2)O(2).17
251251752014Probing muscle ankyrin-repeat protein (MARP) structure and function.17
220167702011Multi-tasking role of the mechanosensing protein Ankrd2 in the signaling network of striated muscle.12
156777382005Expression of Ankrd2 in fast and slow muscles and its response to stretch are consistent with a role in slow muscle function.10
126795962002Altered expression of cardiac ankyrin repeat protein and its homologue, ankyrin repeat protein with PEST and proline-rich region, in atrophic muscles in amyotrophic lateral sclerosis.7
172061052007ARPP protein is selectively expressed in renal oncocytoma, but rarely in renal cell carcinomas.7
244345102014Ankrd2 is a modulator of NF-κB-mediated inflammatory responses during muscle differentiation.7

Citation

Dessen P

ANKRD2 (ankyrin repeat domain 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46185/ankrd2