Atlas of Genetics and Cytogenetics in Oncology and Haematology

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ANPEP (alanyl aminopeptidase, membrane)

Identity

Alias_namesCD13
PEPN
alanyl (membrane) aminopeptidase
Alias_symbol (synonym)LAP1
gp150
p150
Other aliasAPN
GP150
P150
HGNC (Hugo) ANPEP
LocusID (NCBI) 290
Atlas_Id 651
Location 15q26.1  [Link to chromosome band 15q26]
Location_base_pair Starts at 89784895 and ends at 89814840 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ANPEP (15q26.1) / ANPEP (15q26.1)ANPEP (15q26.1) / AP3S2 (15q26.1)CPT1A (11q13.3) / ANPEP (15q26.1)
CUX1 (7q22.1) / ANPEP (15q26.1)CPT1A 11q13.3 / ANPEP 15q26.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(11;15)(q13;q26) CPT1A/ANPEP

External links

Nomenclature
HGNC (Hugo)ANPEP   500
Cards
Entrez_Gene (NCBI)ANPEP  290  alanyl aminopeptidase, membrane
AliasesAPN; CD13; GP150; LAP1; 
P150; PEPN
GeneCards (Weizmann)ANPEP
Ensembl hg19 (Hinxton)ENSG00000166825 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000166825 [Gene_View]  ENSG00000166825 [Sequence]  chr15:89784895-89814840 [Contig_View]  ANPEP [Vega]
ICGC DataPortalENSG00000166825
TCGA cBioPortalANPEP
AceView (NCBI)ANPEP
Genatlas (Paris)ANPEP
WikiGenes290
SOURCE (Princeton)ANPEP
Genetics Home Reference (NIH)ANPEP
Genomic and cartography
GoldenPath hg38 (UCSC)ANPEP  -     chr15:89784895-89814840 -  15q26.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ANPEP  -     15q26.1   [Description]    (hg19-Feb_2009)
GoldenPathANPEP - 15q26.1 [CytoView hg19]  ANPEP - 15q26.1 [CytoView hg38]
ImmunoBaseENSG00000166825
Mapping of homologs : NCBIANPEP [Mapview hg19]  ANPEP [Mapview hg38]
OMIM151530   
Gene and transcription
Genbank (Entrez)AB209918 AK298134 AK298242 AK298339 AK300946
RefSeq transcript (Entrez)NM_001150
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ANPEP
Cluster EST : UnigeneHs.1239 [ NCBI ]
CGAP (NCI)Hs.1239
Alternative Splicing GalleryENSG00000166825
Gene ExpressionANPEP [ NCBI-GEO ]   ANPEP [ EBI - ARRAY_EXPRESS ]   ANPEP [ SEEK ]   ANPEP [ MEM ]
Gene Expression Viewer (FireBrowse)ANPEP [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)290
GTEX Portal (Tissue expression)ANPEP
Human Protein AtlasENSG00000166825-ANPEP [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP15144   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP15144  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP15144
Splice isoforms : SwissVarP15144
Catalytic activity : Enzyme3.4.11.2 [ Enzyme-Expasy ]   3.4.11.23.4.11.2 [ IntEnz-EBI ]   3.4.11.2 [ BRENDA ]   3.4.11.2 [ KEGG ]   
PhosPhoSitePlusP15144
Domaine pattern : Prosite (Expaxy)ZINC_PROTEASE (PS00142)   
Domains : Interpro (EBI)ERAP1-like_C_dom    M1_APN-typ    Peptidase_M1    Peptidase_M1_N   
Domain families : Pfam (Sanger)ERAP1_C (PF11838)    Peptidase_M1 (PF01433)   
Domain families : Pfam (NCBI)pfam11838    pfam01433   
Conserved Domain (NCBI)ANPEP
DMDM Disease mutations290
Blocks (Seattle)ANPEP
PDB (RSDB)4FYQ    4FYR    4FYS    4FYT    5LHD    6ATK   
PDB Europe4FYQ    4FYR    4FYS    4FYT    5LHD    6ATK   
PDB (PDBSum)4FYQ    4FYR    4FYS    4FYT    5LHD    6ATK   
PDB (IMB)4FYQ    4FYR    4FYS    4FYT    5LHD    6ATK   
Structural Biology KnowledgeBase4FYQ    4FYR    4FYS    4FYT    5LHD    6ATK   
SCOP (Structural Classification of Proteins)4FYQ    4FYR    4FYS    4FYT    5LHD    6ATK   
CATH (Classification of proteins structures)4FYQ    4FYR    4FYS    4FYT    5LHD    6ATK   
SuperfamilyP15144
Human Protein Atlas [tissue]ENSG00000166825-ANPEP [tissue]
Peptide AtlasP15144
HPRD01055
IPIIPI00221224   
Protein Interaction databases
DIP (DOE-UCLA)P15144
IntAct (EBI)P15144
FunCoupENSG00000166825
BioGRIDANPEP
STRING (EMBL)ANPEP
ZODIACANPEP
Ontologies - Pathways
QuickGOP15144
Ontology : AmiGOangiogenesis  virus receptor activity  aminopeptidase activity  extracellular space  extracellular space  cytoplasm  lysosomal membrane  endoplasmic reticulum-Golgi intermediate compartment  plasma membrane  plasma membrane  plasma membrane  proteolysis  metallopeptidase activity  zinc ion binding  external side of plasma membrane  integral component of membrane  cell differentiation  secretory granule membrane  signaling receptor activity  peptide binding  peptide catabolic process  neutrophil degranulation  viral entry into host cell  metalloaminopeptidase activity  extracellular exosome  extracellular exosome  
Ontology : EGO-EBIangiogenesis  virus receptor activity  aminopeptidase activity  extracellular space  extracellular space  cytoplasm  lysosomal membrane  endoplasmic reticulum-Golgi intermediate compartment  plasma membrane  plasma membrane  plasma membrane  proteolysis  metallopeptidase activity  zinc ion binding  external side of plasma membrane  integral component of membrane  cell differentiation  secretory granule membrane  signaling receptor activity  peptide binding  peptide catabolic process  neutrophil degranulation  viral entry into host cell  metalloaminopeptidase activity  extracellular exosome  extracellular exosome  
Pathways : KEGGGlutathione metabolism    Renin-angiotensin system    Hematopoietic cell lineage   
NDEx NetworkANPEP
Atlas of Cancer Signalling NetworkANPEP
Wikipedia pathwaysANPEP
Orthology - Evolution
OrthoDB290
GeneTree (enSembl)ENSG00000166825
Phylogenetic Trees/Animal Genes : TreeFamANPEP
HOGENOMP15144
Homologs : HomoloGeneANPEP
Homology/Alignments : Family Browser (UCSC)ANPEP
Gene fusions - Rearrangements
Fusion : MitelmanCPT1A/ANPEP [11q13.3/15q26.1]  [t(11;15)(q13;q26)]  
Fusion PortalCPT1A 11q13.3 ANPEP 15q26.1 KIRC
Fusion : QuiverANPEP
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerANPEP [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ANPEP
dbVarANPEP
ClinVarANPEP
1000_GenomesANPEP 
Exome Variant ServerANPEP
ExAC (Exome Aggregation Consortium)ENSG00000166825
GNOMAD BrowserENSG00000166825
Varsome BrowserANPEP
Genetic variants : HAPMAP290
Genomic Variants (DGV)ANPEP [DGVbeta]
DECIPHERANPEP [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisANPEP 
Mutations
ICGC Data PortalANPEP 
TCGA Data PortalANPEP 
Broad Tumor PortalANPEP
OASIS PortalANPEP [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICANPEP  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DANPEP
Mutations and Diseases : HGMDANPEP
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ANPEP
DgiDB (Drug Gene Interaction Database)ANPEP
DoCM (Curated mutations)ANPEP (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ANPEP (select a term)
intoGenANPEP
Cancer3DANPEP(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM151530   
Orphanet
DisGeNETANPEP
MedgenANPEP
Genetic Testing Registry ANPEP
NextProtP15144 [Medical]
TSGene290
GENETestsANPEP
Target ValidationANPEP
Huge Navigator ANPEP [HugePedia]
snp3D : Map Gene to Disease290
BioCentury BCIQANPEP
ClinGenANPEP
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD290
Chemical/Pharm GKB GenePA24815
Clinical trialANPEP
Miscellaneous
canSAR (ICR)ANPEP (select the gene name)
DataMed IndexANPEP
Probes
Litterature
PubMed140 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineANPEP
EVEXANPEP
GoPubMedANPEP
iHOPANPEP
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Nov 13 17:32:20 CET 2019
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