ANXA2 (annexin A2)

2003-02-01  

Identity

HGNC
LOCATION
15q22.2
LOCUSID
ALIAS
ANX2,ANX2L4,CAL1H,HEL-S-270,LIP2,LPC2,LPC2D,P36,PAP-IV
FUSION GENES

Other Information

Locus ID:

NCBI: 302
MIM: 151740
HGNC: 537
Ensembl: ENSG00000182718

Variants:

dbSNP: 302
ClinVar: 302
TCGA: ENSG00000182718
COSMIC: ANXA2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000182718ENST00000332680P07355
ENSG00000182718ENST00000396024P07355
ENSG00000182718ENST00000396024A0A024R5Z7
ENSG00000182718ENST00000421017P07355
ENSG00000182718ENST00000421017A0A024R5Z7
ENSG00000182718ENST00000451270P07355
ENSG00000182718ENST00000451270A0A024R5Z7
ENSG00000182718ENST00000557904H0YKV8
ENSG00000182718ENST00000557906H0YKS4
ENSG00000182718ENST00000558132H0YNP5
ENSG00000182718ENST00000558169H0YNB8
ENSG00000182718ENST00000558503H0YLV6
ENSG00000182718ENST00000558558H0YKX9
ENSG00000182718ENST00000558985H0YL33
ENSG00000182718ENST00000558986H0YMT9
ENSG00000182718ENST00000558998H0YNA0
ENSG00000182718ENST00000559113H0YN52
ENSG00000182718ENST00000559176H0YM50
ENSG00000182718ENST00000559350H0YMM1
ENSG00000182718ENST00000559370H0YMD9
ENSG00000182718ENST00000559467H0YKZ7
ENSG00000182718ENST00000559725H0YLE2
ENSG00000182718ENST00000559780H0YMW4
ENSG00000182718ENST00000559818H0YN42
ENSG00000182718ENST00000559956H0YKZ7
ENSG00000182718ENST00000560014H0YMU9
ENSG00000182718ENST00000560165H0YKS4
ENSG00000182718ENST00000560367H0YMD0
ENSG00000182718ENST00000560389H0YKS4
ENSG00000182718ENST00000560466H0YN28
ENSG00000182718ENST00000560468H0YKL9
ENSG00000182718ENST00000561022H0YKN4

Expression (GTEx)

0
500
1000
1500
2000

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
HemostasisREACTOMER-HSA-109582
Dissolution of Fibrin ClotREACTOMER-HSA-75205
Muscle contractionREACTOMER-HSA-397014
Smooth Muscle ContractionREACTOMER-HSA-445355
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
186365542008Annexin II/annexin II receptor axis regulates adhesion, migration, homing, and growth of prostate cancer.92
153028702004An annexin 2 phosphorylation switch mediates p11-dependent translocation of annexin 2 to the cell surface.88
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
215725192011Tyrosine 23 phosphorylation-dependent cell-surface localization of annexin A2 is required for invasion and metastases of pancreatic cancer.80
157884162005Metastasis-associated protein S100A4 induces angiogenesis through interaction with Annexin II and accelerated plasmin formation.79
219001672011Annexin II binds to capsid protein VP1 of enterovirus 71 and enhances viral infectivity.79
192890892009Annexin A2-dependent polymerization of actin mediates endosome biogenesis.72
203352582010Role of annexin A2 in the production of infectious hepatitis C virus particles.69
166438922006Angiogenesis-associated protein annexin II in breast cancer: selective expression in invasive breast cancer and contribution to tumor invasion and progression.68
152263722004Annexin 2 is a phosphatidylinositol (4,5)-bisphosphate binding protein recruited to actin assembly sites at cellular membranes.65

Citation

Dessen P

ANXA2 (annexin A2)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/655/anxa2