ANXA6 (annexin A6)

2008-07-01  

Identity

HGNC
ANXA6
LOCATION
5q33.1
LOCUSID
309
ALIAS
ANX6,CBP68,CPB-II,p68,p70
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 309
MIM: 114070
HGNC: 544
Ensembl: ENSG00000197043

Variants:

dbSNP: 309
ClinVar: 309
TCGA: ENSG00000197043
COSMIC: ANXA6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000197043ENST00000354546P08133
ENSG00000197043ENST00000354546A0A0S2Z2Z6
ENSG00000197043ENST00000377751E7EMC6
ENSG00000197043ENST00000517486E5RFF0
ENSG00000197043ENST00000517677E5RI05
ENSG00000197043ENST00000517757E5RJF5
ENSG00000197043ENST00000519644E5RIU8
ENSG00000197043ENST00000521512E5RK69
ENSG00000197043ENST00000521749E5RK63
ENSG00000197043ENST00000522664H0YC77
ENSG00000197043ENST00000523164E5RJR0
ENSG00000197043ENST00000523714P08133

Expression (GTEx)

0
50
100
150
200
250
300
350
400
450
500
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Muscle contractionREACTOMER-HSA-397014
Smooth Muscle ContractionREACTOMER-HSA-445355

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
277011472016Cancer-associated fibroblast-derived annexin A6+ extracellular vesicles support pancreatic cancer aggressiveness.48
178223952007Annexin A6-induced alterations in cholesterol transport and caveolin export from the Golgi complex.30
208883752011Annexin A6-Linking Ca(2+) signaling with cholesterol transport.27
211858312011Annexin A6 contributes to the invasiveness of breast carcinoma cells by influencing the organization and localization of functional focal adhesions.26
193865972009Plasma membrane-associated annexin A6 reduces Ca2+ entry by stabilizing the cortical actin cytoskeleton.25
227970612013Annexin A6 is a scaffold for PKCα to promote EGFR inactivation.24
291584882017Annexin A4 and A6 induce membrane curvature and constriction during cell membrane repair.22
219900382011Annexin A6 is an organizer of membrane microdomains to regulate receptor localization and signalling.21
182450882008Annexin A6-induced inhibition of cytoplasmic phospholipase A2 is linked to caveolin-1 export from the Golgi.19
211196652011Differential expression of ANXA6, HSP27, PRDX2, NCF2, and TPM4 during uterine cervix carcinogenesis: diagnostic and prognostic value.18

Citation

Dessen P

ANXA6 (annexin A6)

Atlas Genet Cytogenet Oncol Haematol. 2008-07-01

Online version: http://atlasgeneticsoncology.org/gene/50196/anxa6