AP1AR (adaptor related protein complex 1 associated regulatory protein)

2014-11-01  

Identity

HGNC
AP1AR
LOCATION
4q25
LOCUSID
55435
ALIAS
2C18,C4orf16,GBAR,PRO0971,gamma-BAR
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 55435
MIM: 610851
HGNC: 28808
Ensembl: ENSG00000138660

Variants:

dbSNP: 55435
ClinVar: 55435
TCGA: ENSG00000138660
COSMIC: AP1AR

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000138660ENST00000274000Q63HQ0
ENSG00000138660ENST00000274000A0A024RDK6
ENSG00000138660ENST00000309703Q63HQ0
ENSG00000138660ENST00000309703A0A024RDI1
ENSG00000138660ENST00000512741H0Y8Y4

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
197064272009Regulation of endosomal membrane traffic by a Gadkin/AP-1/kinesin KIF5 complex.45
215252402011Role of AP1 and Gadkin in the traffic of secretory endo-lysosomes.19
203320992010A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts.8
199658732010A novel subtype of AP-1-binding motif within the palmitoylated trans-Golgi network/endosomal accessory protein Gadkin/gamma-BAR.5

Citation

Dessen P

AP1AR (adaptor related protein complex 1 associated regulatory protein)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/60395/ap1ar