APBB2 (amyloid beta precursor protein binding family B member 2)

2016-10-01 Affiliation

Identity

HGNC

APBB2

LOCATION

4p14

LOCUSID

323

ALIAS

FE65L,FE65L1

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 323
MIM: 602710
HGNC: 582
Ensembl: ENSG00000163697

Variants:

dbSNP: 323
ClinVar: 323
TCGA: ENSG00000163697
COSMIC: APBB2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000163697	ENST00000295974	Q92870
ENSG00000163697	ENST00000502841	Q92870
ENSG00000163697	ENST00000503264	D6RDY3
ENSG00000163697	ENST00000503503	A0A1D5RMR3
ENSG00000163697	ENST00000504305	Q92870
ENSG00000163697	ENST00000506352	G5E9Y1
ENSG00000163697	ENST00000508593	Q92870
ENSG00000163697	ENST00000508676	D6RAE0
ENSG00000163697	ENST00000508707	D6RB00
ENSG00000163697	ENST00000509446	D6RB55
ENSG00000163697	ENST00000510670	D6RD19
ENSG00000163697	ENST00000510925	H0Y943
ENSG00000163697	ENST00000512510	H0YA92
ENSG00000163697	ENST00000513140	Q92870
ENSG00000163697	ENST00000513493	H0Y9U9
ENSG00000163697	ENST00000513516	D6RGD4
ENSG00000163697	ENST00000513611	H0YAJ5
ENSG00000163697	ENST00000514920	D6RAJ4
ENSG00000163697	ENST00000543538	Q92870

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
17567906	2007	Zfra affects TNF-mediated cell death by interacting with death domain protein TRADD and negatively regulates the activation of NF-kappaB, JNK1, p53 and WOX1 during stress response.	26
19542221	2009	Differential processing of amyloid-beta precursor protein directs human embryonic stem cell proliferation and differentiation into neuronal precursor cells.	26
14527950	2003	Generation of the beta-amyloid peptide and the amyloid precursor protein C-terminal fragment gamma are potentiated by FE65L1.	22
20677014	2010	An approach based on a genome-wide association study reveals candidate loci for narcolepsy.	16
15714520	2005	Genetic association of the APP binding protein 2 gene (APBB2) with late onset Alzheimer disease.	11
15714520	2005	Genetic association of the APP binding protein 2 gene (APBB2) with late onset Alzheimer disease.	11
26194614	2015	GSK3β Interactions with Amyloid Genes: An Autopsy Verification and Extension.	6
27157394	2016	Genome-wide expression profiling in the peripheral blood of patients with fibromyalgia.	6
23384821	2013	APBB2 genetic polymorphisms are associated with severe cognitive impairment in centenarians.	4
16083851	2005	The apoptosis inhibitory domain of FE65-like protein 1 regulates both apoptotic and caspase-independent programmed cell death mediated by tumor necrosis factor.	3

Citation

Dessen P

APBB2 (amyloid beta precursor protein binding family B member 2)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/55947/apbb2