Identity
HGNC
LOCATION
Xp11.21
LOCUSID
ALIAS
APE2,APEXL2,XTH2,ZGRF2
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 27301
MIM: 300773
HGNC: 17889
Ensembl: ENSG00000169188
Variants:
dbSNP: 27301
ClinVar: 27301
TCGA: ENSG00000169188
COSMIC: APEX2
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000169188 | ENST00000374987 | Q9UBZ4 |
| ENSG00000169188 | ENST00000374987 | E5KN95 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Base excision repair | KEGG | ko03410 |
| Base excision repair | KEGG | hsa03410 |
| BER complex | KEGG | hsa_M00296 |
| BER complex | KEGG | M00296 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 31828326 | 2020 | APE1 senses DNA single-strand breaks for repair and signaling. | 28 |
| 32111912 | 2020 | Genomic alterations and abnormal expression of APE2 in multiple cancers. | 16 |
| 31828326 | 2020 | APE1 senses DNA single-strand breaks for repair and signaling. | 28 |
| 32111912 | 2020 | Genomic alterations and abnormal expression of APE2 in multiple cancers. | 16 |
| 30686591 | 2019 | Genetic Screens Reveal FEN1 and APEX2 as BRCA2 Synthetic Lethal Targets. | 104 |
| 30805613 | 2019 | Determination of local chromatin interactions using a combined CRISPR and peroxidase APEX2 system. | 22 |
| 31519755 | 2019 | Proteomic mapping by rapamycin-dependent targeting of APEX2 identifies binding partners of VAPB at the inner nuclear membrane. | 22 |
| 30686591 | 2019 | Genetic Screens Reveal FEN1 and APEX2 as BRCA2 Synthetic Lethal Targets. | 104 |
| 30805613 | 2019 | Determination of local chromatin interactions using a combined CRISPR and peroxidase APEX2 system. | 22 |
| 31519755 | 2019 | Proteomic mapping by rapamycin-dependent targeting of APEX2 identifies binding partners of VAPB at the inner nuclear membrane. | 22 |
| 30110897 | 2018 | Single-Strand Break End Resection in Genome Integrity: Mechanism and Regulation by APE2. | 35 |
| 30110897 | 2018 | Single-Strand Break End Resection in Genome Integrity: Mechanism and Regulation by APE2. | 35 |
| 20522537 | 2010 | Variation within DNA repair pathway genes and risk of multiple sclerosis. | 18 |
| 20522537 | 2010 | Variation within DNA repair pathway genes and risk of multiple sclerosis. | 18 |
| 19165527 | 2009 | Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia. | 69 |
Citation
Dessen P
APEX2 (apurinic/apyrimidinic endodeoxyribonuclease 2)
Atlas Genet Cytogenet Oncol Haematol. 2003-12-01
Online version: http://atlasgeneticsoncology.org/gene/670/apex2
