APLP1 (amyloid beta precursor like protein 1)

2008-09-01  

Identity

HGNC
APLP1
LOCATION
19q13.12
LOCUSID
333
ALIAS
APLP
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 333
MIM: 104775
HGNC: 597
Ensembl: ENSG00000105290

Variants:

dbSNP: 333
ClinVar: 333
TCGA: ENSG00000105290
COSMIC: APLP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000105290ENST00000221891P51693
ENSG00000105290ENST00000537454F5GZ08
ENSG00000105290ENST00000586861B7Z4G8
ENSG00000105290ENST00000587274S4R3U6
ENSG00000105290ENST00000588808K7EMN4
ENSG00000105290ENST00000589743K7ELK0
ENSG00000105290ENST00000590561K7EMS1
ENSG00000105290ENST00000592316K7EQJ4
ENSG00000105290ENST00000652533P51693

Expression (GTEx)

0
500
1000
1500
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
146991532004Cleavage of amyloid-beta precursor protein and amyloid-beta precursor-like protein by BACE 1.86
149702122004The proteolytic processing of the amyloid precursor protein gene family members APLP-1 and APLP-2 involves alpha-, beta-, gamma-, and epsilon-like cleavages: modulation of APLP-1 processing by n-glycosylation.71
122282332002Processing of beta-amyloid precursor-like protein-1 and -2 by gamma-secretase regulates transcription.46
191266762009Subcellular localization and dimerization of APLP1 are strikingly different from APP and APLP2.42
200497242009The 28-amino acid form of an APLP1-derived Abeta-like peptide is a surrogate marker for Abeta42 production in the central nervous system.32
152082602004Presence of a "CAGA box" in the APP gene unique to amyloid plaque-forming species and absent in all APLP-1/2 genes: implications in Alzheimer's disease.21
219527902012Structural aspects and physiological consequences of APP/APLP trans-dimerization.17
163445532006Amyloid precursor-like protein 1 influences endocytosis and proteolytic processing of the amyloid precursor protein.15
211782872011Signaling via amyloid precursor-like proteins APLP1 and APLP2.15
256834822015APLP1 and APLP2, members of the APP family of proteins, behave similarly to APP in that they associate with NMDA receptors and enhance NMDA receptor surface expression.15

Citation

Dessen P

APLP1 (amyloid beta precursor like protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2008-09-01

Online version: http://atlasgeneticsoncology.org/gene/50382/aplp1