APLP2 (amyloid beta precursor like protein 2)

2012-01-01  

Identity

HGNC
LOCATION
11q24.3
LOCUSID
ALIAS
APLP-2,APPH,APPL2,CDEBP
FUSION GENES

Other Information

Locus ID:

NCBI: 334
MIM: 104776
HGNC: 598
Ensembl: ENSG00000084234

Variants:

dbSNP: 334
ClinVar: 334
TCGA: ENSG00000084234
COSMIC: APLP2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000084234ENST00000263574Q06481
ENSG00000084234ENST00000278756Q06481
ENSG00000084234ENST00000338167Q06481
ENSG00000084234ENST00000338167A0A140VJE9
ENSG00000084234ENST00000345598Q06481
ENSG00000084234ENST00000528499Q06481
ENSG00000084234ENST00000530132Q9UED0
ENSG00000084234ENST00000533195E9PSC7
ENSG00000084234ENST00000533616E9PPD0
ENSG00000084234ENST00000533713E9PQS3
ENSG00000084234ENST00000534582E9PK76
ENSG00000084234ENST00000650012Q06481

Expression (GTEx)

0
100
200
300
400
500
600
700

Pathways

PathwaySourceExternal ID
HemostasisREACTOMER-HSA-109582
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Response to elevated platelet cytosolic Ca2+REACTOMER-HSA-76005
Platelet degranulationREACTOMER-HSA-114608

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
146991532004Cleavage of amyloid-beta precursor protein and amyloid-beta precursor-like protein by BACE 1.86
149702122004The proteolytic processing of the amyloid precursor protein gene family members APLP-1 and APLP-2 involves alpha-, beta-, gamma-, and epsilon-like cleavages: modulation of APLP-1 processing by n-glycosylation.71
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
122282332002Processing of beta-amyloid precursor-like protein-1 and -2 by gamma-secretase regulates transcription.46
191266762009Subcellular localization and dimerization of APLP1 are strikingly different from APP and APLP2.42
263130042015APLP2 Regulates Refractive Error and Myopia Development in Mice and Humans.25
162799452005Shedding of the amyloid precursor protein-like protein APLP2 by disintegrin-metalloproteinases.23
152082602004Presence of a "CAGA box" in the APP gene unique to amyloid plaque-forming species and absent in all APLP-1/2 genes: implications in Alzheimer's disease.21
216950602011Determination of the proteolytic cleavage sites of the amyloid precursor-like protein 2 by the proteases ADAM10, BACE1 and γ-secretase.20
260851042015Amyloid Precursor-like Protein 2 and Sortilin Do Not Regulate the PCSK9 Convertase-mediated Low Density Lipoprotein Receptor Degradation but Interact with Each Other.20

Citation

Dessen P

APLP2 (amyloid beta precursor like protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2012-01-01

Online version: http://atlasgeneticsoncology.org/gene/52577/aplp2