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APOA2 (apolipoprotein A-II)

Identity

Other namesApo-AII
ApoA-II
apoAII
HGNC (Hugo) APOA2
LocusID (NCBI) 336
Location 1q23.3
Location_base_pair Starts at 161192083 and ends at 161193418 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

External links

Nomenclature
HGNC (Hugo)APOA2   601
Cards
Entrez_Gene (NCBI)APOA2  336  apolipoprotein A-II
GeneCards (Weizmann)APOA2
Ensembl hg19 (Hinxton)ENSG00000158874 [Gene_View]  chr1:161192083-161193418 [Contig_View]  APOA2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000158874 [Gene_View]  chr1:161192083-161193418 [Contig_View]  APOA2 [Vega]
ICGC DataPortalENSG00000158874
cBioPortalAPOA2
AceView (NCBI)APOA2
Genatlas (Paris)APOA2
WikiGenes336
SOURCE (Princeton)APOA2
Genomic and cartography
GoldenPath hg19 (UCSC)APOA2  -     chr1:161192083-161193418 -  1q23.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)APOA2  -     1q23.3   [Description]    (hg38-Dec_2013)
EnsemblAPOA2 - 1q23.3 [CytoView hg19]  APOA2 - 1q23.3 [CytoView hg38]
Mapping of homologs : NCBIAPOA2 [Mapview hg19]  APOA2 [Mapview hg38]
OMIM107670   143890   
Gene and transcription
Genbank (Entrez)AB106565 AK312034 BC005282 BT006786 DQ892493
RefSeq transcript (Entrez)NM_001643
RefSeq genomic (Entrez)AC_000133 NC_000001 NC_018912 NG_012043 NT_004487 NW_001838531 NW_004929293
Consensus coding sequences : CCDS (NCBI)APOA2
Cluster EST : UnigeneHs.237658 [ NCBI ]
CGAP (NCI)Hs.237658
Alternative Splicing : Fast-db (Paris)GSHG0002677
Alternative Splicing GalleryENSG00000158874
Gene ExpressionAPOA2 [ NCBI-GEO ]     APOA2 [ SEEK ]   APOA2 [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP02652 (Uniprot)
NextProtP02652  [Medical]
With graphics : InterProP02652
Splice isoforms : SwissVarP02652 (Swissvar)
Domains : Interpro (EBI)ApoA-II   
Related proteins : CluSTrP02652
Domain families : Pfam (Sanger)ApoA-II (PF04711)   
Domain families : Pfam (NCBI)pfam04711   
Domain structure : Prodom (Prabi Lyon)ApoA-II (PD010397)   
DMDM Disease mutations336
Blocks (Seattle)P02652
PDB (SRS)1L6L    2OU1   
PDB (PDBSum)1L6L    2OU1   
PDB (IMB)1L6L    2OU1   
PDB (RSDB)1L6L    2OU1   
Human Protein AtlasENSG00000158874
Peptide AtlasP02652
HPRD00129
IPIIPI00021854   IPI00446657   
Protein Interaction databases
DIP (DOE-UCLA)P02652
IntAct (EBI)P02652
FunCoupENSG00000158874
BioGRIDAPOA2
IntegromeDBAPOA2
STRING (EMBL)APOA2
Ontologies - Pathways
QuickGOP02652
Ontology : AmiGOretinoid metabolic process  acute inflammatory response  negative regulation of cytokine secretion involved in immune response  lipid transporter activity  protein binding  phospholipid binding  extracellular region  extracellular region  early endosome  endoplasmic reticulum lumen  cytosol  protein folding  triglyceride metabolic process  phosphatidylcholine biosynthetic process  phototransduction, visible light  high-density lipoprotein particle binding  cholesterol metabolic process  lipid binding  phospholipid catabolic process  response to glucose  positive regulation of cholesterol esterification  negative regulation of very-low-density lipoprotein particle remodeling  cholesterol binding  viral process  cholesterol transporter activity  protein oxidation  peptidyl-methionine modification  regulation of intestinal cholesterol absorption  organ regeneration  phosphatidylcholine binding  regulation of protein stability  negative regulation of cholesterol transport  cholesterol efflux  phospholipid efflux  apolipoprotein receptor binding  very-low-density lipoprotein particle  high-density lipoprotein particle  spherical high-density lipoprotein particle  triglyceride-rich lipoprotein particle remodeling  low-density lipoprotein particle remodeling  high-density lipoprotein particle remodeling  high-density lipoprotein particle assembly  high-density lipoprotein particle clearance  lipoprotein metabolic process  response to drug  chylomicron  cholesterol homeostasis  protein homodimerization activity  positive regulation of catalytic activity  response to estrogen  reverse cholesterol transport  cellular lipid metabolic process  small molecule metabolic process  positive regulation of interleukin-8 biosynthetic process  diacylglycerol catabolic process  protein heterodimerization activity  negative regulation of lipid catabolic process  positive regulation of lipid catabolic process  response to glucocorticoid  lipase inhibitor activity  negative regulation of lipase activity  phosphatidylcholine-sterol O-acyltransferase activator activity  negative regulation of cholesterol import  negative regulation of cholesterol transporter activity  extracellular vesicular exosome  high-density lipoprotein particle receptor binding  blood microparticle  
Ontology : EGO-EBIretinoid metabolic process  acute inflammatory response  negative regulation of cytokine secretion involved in immune response  lipid transporter activity  protein binding  phospholipid binding  extracellular region  extracellular region  early endosome  endoplasmic reticulum lumen  cytosol  protein folding  triglyceride metabolic process  phosphatidylcholine biosynthetic process  phototransduction, visible light  high-density lipoprotein particle binding  cholesterol metabolic process  lipid binding  phospholipid catabolic process  response to glucose  positive regulation of cholesterol esterification  negative regulation of very-low-density lipoprotein particle remodeling  cholesterol binding  viral process  cholesterol transporter activity  protein oxidation  peptidyl-methionine modification  regulation of intestinal cholesterol absorption  organ regeneration  phosphatidylcholine binding  regulation of protein stability  negative regulation of cholesterol transport  cholesterol efflux  phospholipid efflux  apolipoprotein receptor binding  very-low-density lipoprotein particle  high-density lipoprotein particle  spherical high-density lipoprotein particle  triglyceride-rich lipoprotein particle remodeling  low-density lipoprotein particle remodeling  high-density lipoprotein particle remodeling  high-density lipoprotein particle assembly  high-density lipoprotein particle clearance  lipoprotein metabolic process  response to drug  chylomicron  cholesterol homeostasis  protein homodimerization activity  positive regulation of catalytic activity  response to estrogen  reverse cholesterol transport  cellular lipid metabolic process  small molecule metabolic process  positive regulation of interleukin-8 biosynthetic process  diacylglycerol catabolic process  protein heterodimerization activity  negative regulation of lipid catabolic process  positive regulation of lipid catabolic process  response to glucocorticoid  lipase inhibitor activity  negative regulation of lipase activity  phosphatidylcholine-sterol O-acyltransferase activator activity  negative regulation of cholesterol import  negative regulation of cholesterol transporter activity  extracellular vesicular exosome  high-density lipoprotein particle receptor binding  blood microparticle  
Pathways : BIOCARTAMechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha) [Genes]   
Pathways : KEGGPPAR signaling pathway   
Protein Interaction DatabaseAPOA2
DoCM (Curated mutations)APOA2
Wikipedia pathwaysAPOA2
Gene fusion - rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerAPOA2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)APOA2
dbVarAPOA2
ClinVarAPOA2
1000_GenomesAPOA2 
Exome Variant ServerAPOA2
SNP (GeneSNP Utah)APOA2
SNP : HGBaseAPOA2
Genetic variants : HAPMAPAPOA2
Genomic VariantsAPOA2  APOA2 [DGVbeta]
Mutations
ICGC Data PortalENSG00000158874 
Somatic Mutations in Cancer : COSMICAPOA2 
CONAN: Copy Number AnalysisAPOA2 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)1:161192083-161193418
Mutations and Diseases : HGMDAPOA2
OMIM107670    143890   
MedgenAPOA2
NextProtP02652 [Medical]
GENETestsAPOA2
Disease Genetic AssociationAPOA2
Huge Navigator APOA2 [HugePedia]  APOA2 [HugeCancerGEM]
snp3D : Map Gene to Disease336
DGIdb (Drug Gene Interaction db)APOA2
General knowledge
Homologs : HomoloGeneAPOA2
Homology/Alignments : Family Browser (UCSC)APOA2
Phylogenetic Trees/Animal Genes : TreeFamAPOA2
Chemical/Protein Interactions : CTD336
Chemical/Pharm GKB GenePA24886
Clinical trialAPOA2
Cancer Resource (Charite)ENSG00000158874
Other databases
Probes
Litterature
PubMed132 Pubmed reference(s) in Entrez
CoreMineAPOA2
GoPubMedAPOA2
iHOPAPOA2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2014Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Dec 20 20:10:36 CET 2014

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