APOA4 (apolipoprotein A4)

2009-06-01  

Identity

HGNC
LOCATION
11q23.3
LOCUSID
ALIAS
-

Other Information

Locus ID:

NCBI: 337
MIM: 107690
HGNC: 602
Ensembl: ENSG00000110244

Variants:

dbSNP: 337
ClinVar: 337
TCGA: ENSG00000110244
COSMIC: APOA4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000110244ENST00000357780P06727

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Fat digestion and absorptionKEGGko04975
Fat digestion and absorptionKEGGhsa04975
Vitamin digestion and absorptionKEGGko04977
Vitamin digestion and absorptionKEGGhsa04977
Metabolism of proteinsREACTOMER-HSA-392499
Amyloid fiber formationREACTOMER-HSA-977225
Signal TransductionREACTOMER-HSA-162582
Visual phototransductionREACTOMER-HSA-2187338
Retinoid metabolism and transportREACTOMER-HSA-975634
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Lipid digestion, mobilization, and transportREACTOMER-HSA-73923
Lipoprotein metabolismREACTOMER-HSA-174824
Chylomicron-mediated lipid transportREACTOMER-HSA-174800
Metabolism of vitamins and cofactorsREACTOMER-HSA-196854
Metabolism of fat-soluble vitaminsREACTOMER-HSA-6806667

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA273PLTPGenePathwayassociated

References

Pubmed IDYearTitleCitations
380969512024Autosomal dominant ApoA4 mutations present as tubulointerstitial kidney disease with medullary amyloidosis.0
386437172024Apolipoprotein A-IV polymorphisms Q360H and T347S attenuate its endogenous inhibition of thrombosis.0
380969512024Autosomal dominant ApoA4 mutations present as tubulointerstitial kidney disease with medullary amyloidosis.0
386437172024Apolipoprotein A-IV polymorphisms Q360H and T347S attenuate its endogenous inhibition of thrombosis.0
367758682023Apolipoprotein A-IV of diabetic-foot patients upregulates tumor necrosis factor α expression in microfluidic arterial models.0
370925492023The distinct metabolism between large and small HDL indicates unique origins of human apolipoprotein A4.3
367758682023Apolipoprotein A-IV of diabetic-foot patients upregulates tumor necrosis factor α expression in microfluidic arterial models.0
370925492023The distinct metabolism between large and small HDL indicates unique origins of human apolipoprotein A4.3
195927052022PEA-15 engages in allosteric interactions using a common scaffold in a phosphorylation-dependent manner.24
195927052022PEA-15 engages in allosteric interactions using a common scaffold in a phosphorylation-dependent manner.24
362842902022Serum apolipoprotein A-IV levels are associated with flow-mediated dilation in patients with type 2 diabetes mellitus.0
366141132022Apolipoprotein A-IV Has Bi-Functional Actions in Alcoholic Hepatitis by Regulating Hepatocyte Injury and Immune Cell Infiltration.2
195927052022PEA-15 engages in allosteric interactions using a common scaffold in a phosphorylation-dependent manner.24
195927052022PEA-15 engages in allosteric interactions using a common scaffold in a phosphorylation-dependent manner.24
362842902022Serum apolipoprotein A-IV levels are associated with flow-mediated dilation in patients with type 2 diabetes mellitus.0

Citation

Dessen P

APOA4 (apolipoprotein A4)

Atlas Genet Cytogenet Oncol Haematol. 2009-06-01

Online version: http://atlasgeneticsoncology.org/gene/50976/apoa4