APOBEC1 (apolipoprotein B mRNA editing enzyme catalytic subunit 1)

2003-05-01 Affiliation

Identity

HGNC

APOBEC1

LOCATION

12p13.31

LOCUSID

339

ALIAS

APOBEC-1,BEDP,CDAR1,HEPR

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 339
MIM: 600130
HGNC: 604
Ensembl: ENSG00000111701

Variants:

dbSNP: 339
ClinVar: 339
TCGA: ENSG00000111701
COSMIC: APOBEC1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000111701	ENST00000229304	P41238
ENSG00000111701	ENST00000467171	A0A0B4J232

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Gene Expression	REACTOME	R-HSA-74160
mRNA Editing	REACTOME	R-HSA-75072
mRNA Editing: C to U Conversion	REACTOME	R-HSA-72200
Formation of the Editosome	REACTOME	R-HSA-75094

References

Pubmed ID	Year	Title	Citations
25839328	2015	Genomic analyses reveal mutational signatures and frequently altered genes in esophageal squamous cell carcinoma.	95
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
12881431	2003	The apolipoprotein B mRNA editing complex performs a multifunctional cycle and suppresses nonsense-mediated decay.	50
20331378	2010	Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus.	29
25085003	2014	The RNA editing enzyme APOBEC1 induces somatic mutations and a compatible mutational signature is present in esophageal adenocarcinomas.	29
12896982	2003	A novel nuclear localization signal in the auxiliary domain of apobec-1 complementation factor regulates nucleocytoplasmic import and shuttling.	24
11815617	2002	Two proteins essential for apolipoprotein B mRNA editing are expressed from a single gene through alternative splicing.	16
16999936	2006	APOBEC-1 and AID are nucleo-cytoplasmic trafficking proteins but APOBEC3G cannot traffic.	16
11727199	2002	C-->U editing of neurofibromatosis 1 mRNA occurs in tumors that express both the type II transcript and apobec-1, the catalytic subunit of the apolipoprotein B mRNA-editing enzyme.	15
19911124	2009	APOBEC deaminases-mutases with defensive roles for immunity.	14

Citation

Dessen P

APOBEC1 (apolipoprotein B mRNA editing enzyme catalytic subunit 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/676/apobec1