APOBEC3C (apolipoprotein B mRNA editing enzyme catalytic subunit 3C)

2007-02-01  

Identity

HGNC
LOCATION
22q13.1
LOCUSID
ALIAS
A3C,APOBEC1L,ARDC2,ARDC4,ARP5,PBI,bK150C2.3
FUSION GENES

Other Information

Locus ID:

NCBI: 27350
MIM: 607750
HGNC: 17353
Ensembl: ENSG00000244509

Variants:

dbSNP: 27350
ClinVar: 27350
TCGA: ENSG00000244509
COSMIC: APOBEC3C

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000244509ENST00000361441Q9NRW3
ENSG00000244509ENST00000428892F8WB92

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
mRNA EditingREACTOMER-HSA-75072
mRNA Editing: C to U ConversionREACTOMER-HSA-72200
Formation of the EditosomeREACTOMER-HSA-75094

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
167355042006APOBEC3 proteins inhibit human LINE-1 retrotransposition.210
154668722004APOBEC3B and APOBEC3C are potent inhibitors of simian immunodeficiency virus replication.159
200961412010Interactions of host APOBEC3 restriction factors with HIV-1 in vivo: implications for therapeutics.110
173719412007Myeloid differentiation and susceptibility to HIV-1 are linked to APOBEC3 expression.109
230010052012The APOBEC3C crystal structure and the interface for HIV-1 Vif binding.88
183912172008Cytidine deamination induced HIV-1 drug resistance.84
213682042011Somatic hypermutation of human mitochondrial and nuclear DNA by APOBEC3 cytidine deaminases, a pathway for DNA catabolism.81
159565652005Differential sensitivity of murine leukemia virus to APOBEC3-mediated inhibition is governed by virion exclusion.74
175820062007Differential inhibition of long interspersed element 1 by APOBEC3 does not correlate with high-molecular-mass-complex formation or P-body association.68
180324892008Species-specific restriction of apobec3-mediated hypermutation.52

Citation

Dessen P

APOBEC3C (apolipoprotein B mRNA editing enzyme catalytic subunit 3C)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/50033/apobec3c