APOF (apolipoprotein F)

2012-03-01 Affiliation

Identity

HGNC

APOF

LOCATION

12q13.3

LOCUSID

319

ALIAS

Apo-F,LTIP

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 319
MIM: 107760
HGNC: 615
Ensembl: ENSG00000175336

Variants:

dbSNP: 319
ClinVar: 319
TCGA: ENSG00000175336
COSMIC: APOF

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000175336	ENST00000398189	Q13790

Expression (GTEx)

100

150

200

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Metabolism	REACTOME	R-HSA-1430728
Metabolism of lipids and lipoproteins	REACTOME	R-HSA-556833
Lipid digestion, mobilization, and transport	REACTOME	R-HSA-73923
Lipoprotein metabolism	REACTOME	R-HSA-174824
LDL-mediated lipid transport	REACTOME	R-HSA-171052

References

Pubmed ID	Year	Title	Citations
20331378	2010	Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus.	29
19878569	2009	Candidate genetic analysis of plasma high-density lipoprotein-cholesterol and severity of coronary atherosclerosis.	28
20855565	2010	Common genetic variation in multiple metabolic pathways influences susceptibility to low HDL-cholesterol and coronary heart disease.	27
17901467	2008	Lipid transfer inhibitor protein (apolipoprotein F) concentration in normolipidemic and hyperlipidemic subjects.	16
12907677	2003	Lipid transfer inhibitor protein defines the participation of high density lipoprotein subfractions in lipid transfer reactions mediated by cholesterol ester transfer protein (CETP).	11
18369235	2008	Control of cholesteryl ester transfer protein activity by sequestration of lipid transfer inhibitor protein in an inactive complex.	9
20691829	2010	Joint effects of common genetic variants from multiple genes and pathways on the risk of premature coronary artery disease.	8
15172102	2004	Exclusion of CYP46 and APOM as candidate genes for Alzheimer's disease in a French population.	4
21937674	2011	Conversion of lipid transfer inhibitor protein (apolipoprotein F) to its active form depends on LDL composition.	3
25726912	2015	Transcriptional regulation of the apolipoprotein F (ApoF) gene by ETS and C/EBPα in hepatoma cells.	3

Citation

Dessen P

APOF (apolipoprotein F)

Atlas Genet Cytogenet Oncol Haematol. 2012-03-01

Online version: http://atlasgeneticsoncology.org/gene/52661/apof