APPL1 (adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1)
2003-02-01 AffiliationIdentity
HGNC
LOCATION
3p14.3
LOCUSID
ALIAS
APPL,DIP13alpha,MODY14
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 26060
MIM: 604299
HGNC: 24035
Ensembl: ENSG00000157500
Variants:
dbSNP: 26060
ClinVar: 26060
TCGA: ENSG00000157500
COSMIC: APPL1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000157500 | ENST00000288266 | Q9UKG1 |
| ENSG00000157500 | ENST00000444459 | C9JAB0 |
| ENSG00000157500 | ENST00000495803 | C9K0C4 |
| ENSG00000157500 | ENST00000650354 | Q9UKG1 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36089417 | 2023 | Aberrant protein expression of Appl1, Sortilin and Syndecan-1 during the biological progression of prostate cancer. | 8 |
| 36846720 | 2023 | APPL1 Is a Prognostic Biomarker and Correlated with Treg Cell Infiltration via Oxygen-Consuming Metabolism in Renal Clear Cell Carcinoma. | 2 |
| 37187293 | 2023 | Reduced APPL1 impairs osteogenic differentiation of mesenchymal stem cells by facilitating MGP expression to disrupt the BMP2 pathway in osteoporosis. | 1 |
| 37795615 | 2023 | Dysfunctional APPL1-Mediated Epigenetic Regulation in Diabetic Vascular Injury. | 0 |
| 36089417 | 2023 | Aberrant protein expression of Appl1, Sortilin and Syndecan-1 during the biological progression of prostate cancer. | 8 |
| 36846720 | 2023 | APPL1 Is a Prognostic Biomarker and Correlated with Treg Cell Infiltration via Oxygen-Consuming Metabolism in Renal Clear Cell Carcinoma. | 2 |
| 37187293 | 2023 | Reduced APPL1 impairs osteogenic differentiation of mesenchymal stem cells by facilitating MGP expression to disrupt the BMP2 pathway in osteoporosis. | 1 |
| 37795615 | 2023 | Dysfunctional APPL1-Mediated Epigenetic Regulation in Diabetic Vascular Injury. | 0 |
| 35984564 | 2022 | Impairment of APPL1/Myoferlin facilitates adipogenic differentiation of mesenchymal stem cells by blocking autophagy flux in osteoporosis. | 3 |
| 35984564 | 2022 | Impairment of APPL1/Myoferlin facilitates adipogenic differentiation of mesenchymal stem cells by blocking autophagy flux in osteoporosis. | 3 |
| 33597720 | 2021 | Rapid whole cell imaging reveals a calcium-APPL1-dynein nexus that regulates cohort trafficking of stimulated EGF receptors. | 7 |
| 33597720 | 2021 | Rapid whole cell imaging reveals a calcium-APPL1-dynein nexus that regulates cohort trafficking of stimulated EGF receptors. | 7 |
| 32339379 | 2020 | APPL1 as an important regulator of insulin and adiponectin-signaling pathways in the PCOS: A narrative review. | 7 |
| 32339379 | 2020 | APPL1 as an important regulator of insulin and adiponectin-signaling pathways in the PCOS: A narrative review. | 7 |
| 29361527 | 2018 | α5β1 integrin trafficking and Rac activation are regulated by APPL1 in a Rab5-dependent manner to inhibit cell migration. | 7 |
Citation
Dessen P
APPL1 (adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1)
Atlas Genet Cytogenet Oncol Haematol. 2003-02-01
Online version: http://atlasgeneticsoncology.org/gene/680/appl1
