AQP7 (aquaporin 7)

2017-04-01 Affiliation

Identity

HGNC

AQP7

LOCATION

9p13.3

LOCUSID

364

ALIAS

AQP7L,AQPap,GLYCQTL

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 364
MIM: 602974
HGNC: 640
Ensembl: ENSG00000165269

Variants:

dbSNP: 364
ClinVar: 364
TCGA: ENSG00000165269
COSMIC: AQP7

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000165269	ENST00000297988	O14520
ENSG00000165269	ENST00000377425	Q6P5T0
ENSG00000165269	ENST00000379506	Q5T5M0
ENSG00000165269	ENST00000379507	Q5T5M1
ENSG00000165269	ENST00000439678	Q5T5L3
ENSG00000165269	ENST00000447660	O14520
ENSG00000165269	ENST00000537089	A0A096LNU3
ENSG00000165269	ENST00000624005	A0A096LNU3
ENSG00000165269	ENST00000624075	B7Z4U2
ENSG00000165269	ENST00000624095	A0A096LP64
ENSG00000165269	ENST00000624420	A0A096LP23
ENSG00000165269	ENST00000624890	A0A096LNN5
ENSG00000165269	ENST00000625032	A0A096LNV7
ENSG00000165269	ENST00000625109	A0A096LNK2

Expression (GTEx)

100

150

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
PPAR signaling pathway	KEGG	ko03320
PPAR signaling pathway	KEGG	hsa03320
Regulation of lipolysis in adipocytes	KEGG	hsa04923
Transmembrane transport of small molecules	REACTOME	R-HSA-382551
Aquaporin-mediated transport	REACTOME	R-HSA-445717
Passive transport by Aquaporins	REACTOME	R-HSA-432047
Transport of glycerol from adipocytes to the liver by Aquaporins	REACTOME	R-HSA-432030

References

Pubmed ID	Year	Title	Citations
11952783	2002	Human aquaporin adipose (AQPap) gene. Genomic structure, promoter analysis and functional mutation.	28
24463099	2014	Metabolic impact of the glycerol channels AQP7 and AQP9 in adipose tissue and liver.	25
16325777	2006	Differential expression of aquaporin 7 in adipose tissue of lean and obese high fat consumers.	24
17351148	2007	A functional variant of the adipocyte glycerol channel aquaporin 7 gene is associated with obesity and related metabolic abnormalities.	22
17351148	2007	A functional variant of the adipocyte glycerol channel aquaporin 7 gene is associated with obesity and related metabolic abnormalities.	22
17566090	2007	Adipose tissue expression of the glycerol channel aquaporin-7 gene is altered in severe obesity but not in type 2 diabetes.	18
18401671	2008	Influence of morbid obesity and insulin resistance on gene expression levels of AQP7 in visceral adipose tissue and AQP9 in liver.	18
20463097	2010	Paired subcutaneous and visceral adipose tissue aquaporin-7 expression in human obesity and type 2 diabetes: differences and similarities between depots.	17
22425521	2012	Implications of aquaglyceroporins 7 and 9 in glycerol metabolism and metabolic syndrome.	14
24376702	2013	Biophysical assessment of human aquaporin-7 as a water and glycerol channel in 3T3-L1 adipocytes.	13

Citation

Dessen P

AQP7 (aquaporin 7)

Atlas Genet Cytogenet Oncol Haematol. 2017-04-01

Online version: http://atlasgeneticsoncology.org/gene/56897/aqp7