AQP8 (aquaporin 8)

2007-02-01  

Identity

HGNC
LOCATION
16p12.1
LOCUSID
ALIAS
AQP-8

Other Information

Locus ID:

NCBI: 343
MIM: 603750
HGNC: 642
Ensembl: ENSG00000103375

Variants:

dbSNP: 343
ClinVar: 343
TCGA: ENSG00000103375
COSMIC: AQP8

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000103375ENST00000219660O94778
ENSG00000103375ENST00000566125A0A0C4DGL6

Expression (GTEx)

0
50
100
150
200
250
300

Pathways

PathwaySourceExternal ID
Bile secretionKEGGko04976
Bile secretionKEGGhsa04976
Transmembrane transport of small moleculesREACTOMER-HSA-382551
Aquaporin-mediated transportREACTOMER-HSA-445717
Passive transport by AquaporinsREACTOMER-HSA-432047
Cellular responses to stressREACTOMER-HSA-2262752
Detoxification of Reactive Oxygen SpeciesREACTOMER-HSA-3299685

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
93250991997The high resolution crystal structure of deoxyhemoglobin S.36
244402772014Specific aquaporins facilitate Nox-produced hydrogen peroxide transport through plasma membrane in leukaemia cells.30
269723852016Stress Regulates Aquaporin-8 Permeability to Impact Cell Growth and Survival.30
112318872001Differential expression of aquaporin 8 in human colonic epithelial cells and colorectal tumors.29
174614712007Aquaporin-8 expression is reduced in ileum and induced in colon of patients with ulcerative colitis.17
280428262016Aquaporin-Mediated Water and Hydrogen Peroxide Transport Is Involved in Normal Human Spermatozoa Functioning.13
240550342013Expression of aquaporin8 in human astrocytomas: correlation with pathologic grade.12
207327712010The expression of aquaporin 8 and aquaporin 9 in fetal membranes and placenta in term pregnancies complicated by idiopathic polyhydramnios.10
229011562012Significance and expression of aquaporin 1, 3, 8 in cervical carcinoma in Xinjiang Uygur women of China.9
255508022014Aquaporin-8 mediates human esophageal cancer Eca-109 cell migration via the EGFR-Erk1/2 pathway.9

Citation

Dessen P

AQP8 (aquaporin 8)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46536/aqp8