ARFIP2 (ADP ribosylation factor interacting protein 2)

2003-02-01  

Identity

HGNC
ARFIP2
LOCATION
11p15.4
LOCUSID
23647
ALIAS
POR1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 23647
MIM: 601638
HGNC: 17160
Ensembl: ENSG00000132254

Variants:

dbSNP: 23647
ClinVar: 23647
TCGA: ENSG00000132254
COSMIC: ARFIP2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000132254ENST00000254584P53365
ENSG00000132254ENST00000396777P53365
ENSG00000132254ENST00000423813P53365
ENSG00000132254ENST00000445086P53365
ENSG00000132254ENST00000525235E9PRV8
ENSG00000132254ENST00000531037E9PPY7
ENSG00000132254ENST00000614314A0A087X1E4

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Intra-Golgi and retrograde Golgi-to-ER trafficREACTOMER-HSA-6811442
Retrograde transport at the Trans-Golgi-NetworkREACTOMER-HSA-6811440

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
236953572013Recruitment of arfaptins to the trans-Golgi network by PI(4)P and their involvement in cargo export.18
158093042005Phosphorylation of arfaptin 2 at Ser260 by Akt Inhibits PolyQ-huntingtin-induced toxicity by rescuing proteasome impairment.17
226790202012Structural basis for membrane binding specificity of the Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin-2 determined by Arl1 GTPase.12
118547522002Arfaptin 2 regulates the aggregation of mutant huntingtin protein.9
236381702013Arf1 and membrane curvature cooperate to recruit Arfaptin2 to liposomes.6
262966582015Dimer of arfaptin 2 regulates NF-κB signaling by interacting with IKKβ/NEMO and inhibiting IKKβ kinase activity.1

Citation

Dessen P

ARFIP2 (ADP ribosylation factor interacting protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/691/arfip2