Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 383
MIM: 608313
HGNC: 663
Ensembl: ENSG00000118520
Variants:
dbSNP: 383
ClinVar: 383
TCGA: ENSG00000118520
COSMIC: ARG1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000118520 | ENST00000356962 | P05089 |
| ENSG00000118520 | ENST00000368087 | P05089 |
| ENSG00000118520 | ENST00000640973 | P05089 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA134687887 | selective beta-2-adrenoreceptor agonists | Chemical | ClinicalAnnotation | associated | PD | ||
| PA166176020 | sodium benzoate / sodium phenylacetate | Chemical | LabelAnnotation | associated | |||
| PA443450 | Asthma | Disease | ClinicalAnnotation | associated | PD |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37996700 | 2024 | DDR2-regulated arginase activity in ovarian cancer-associated fibroblasts promotes collagen production and tumor progression. | 4 |
| 38369188 | 2024 | Quantitative Multiplexed Analysis of Indoleamine 2,3-Dioxygenase (IDO) and Arginase-1 (ARG1) Expression and Myeloid Cell Infiltration in Colorectal Cancer. | 0 |
| 38374190 | 2024 | Arginase-induced cell death pathways and metabolic changes in cancer cells are not altered by insulin. | 0 |
| 37996700 | 2024 | DDR2-regulated arginase activity in ovarian cancer-associated fibroblasts promotes collagen production and tumor progression. | 4 |
| 38369188 | 2024 | Quantitative Multiplexed Analysis of Indoleamine 2,3-Dioxygenase (IDO) and Arginase-1 (ARG1) Expression and Myeloid Cell Infiltration in Colorectal Cancer. | 0 |
| 38374190 | 2024 | Arginase-induced cell death pathways and metabolic changes in cancer cells are not altered by insulin. | 0 |
| 36309295 | 2023 | Pathophysiological correlation of arginase-1 in development of type 2 diabetes from obesity in adolescents. | 0 |
| 36524315 | 2023 | Arginase-1+ bone marrow myeloid cells are reduced in myeloproliferative neoplasms and correlate with clinical phenotype, fibrosis, and molecular driver. | 5 |
| 36727849 | 2023 | Arginase 1 is a key driver of immune suppression in pancreatic cancer. | 22 |
| 37723490 | 2023 | Arginase-1 promotes lens epithelial-to-mesenchymal transition in different models of anterior subcapsular cataract. | 0 |
| 36309295 | 2023 | Pathophysiological correlation of arginase-1 in development of type 2 diabetes from obesity in adolescents. | 0 |
| 36524315 | 2023 | Arginase-1+ bone marrow myeloid cells are reduced in myeloproliferative neoplasms and correlate with clinical phenotype, fibrosis, and molecular driver. | 5 |
| 36727849 | 2023 | Arginase 1 is a key driver of immune suppression in pancreatic cancer. | 22 |
| 37723490 | 2023 | Arginase-1 promotes lens epithelial-to-mesenchymal transition in different models of anterior subcapsular cataract. | 0 |
| 34902507 | 2022 | Expression dynamics of the immune mediators ARG1, TBET, CIITA, IL10 and TGFB1 in chronic myeloid leukaemia patients during the first year of imatinib therapy. | 0 |
Citation
Dessen P
ARG1 (arginase 1)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/43917/arg1
