ARHGAP15 (Rho GTPase activating protein 15)

2006-10-01  

Identity

HGNC
LOCATION
2q22.2
LOCUSID
ALIAS
BM046
FUSION GENES

Other Information

Locus ID:

NCBI: 55843
MIM: 610578
HGNC: 21030
Ensembl: ENSG00000075884

Variants:

dbSNP: 55843
ClinVar: 55843
TCGA: ENSG00000075884
COSMIC: ARHGAP15

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000075884ENST00000295095Q53QZ3
ENSG00000075884ENST00000409869B8ZZK0
ENSG00000075884ENST00000419455H7BZM0

Expression (GTEx)

0
5
10
15
20
25
30
35

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
Rho GTPase cycleREACTOMER-HSA-194840

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
126509402003ArhGAP15, a novel human RacGAP protein with GTPase binding property.29
212970762011Haplotype association mapping of acute lung injury in mice implicates activin a receptor, type 1.18
204680712010Evidence for genes on chromosome 2 contributing to alcohol dependence with conduct disorder and suicide attempts.17
237602702013ArhGAP15, a Rac-specific GTPase-activating protein, plays a dual role in inhibiting small GTPase signaling.13
285855512017Sequence variants in ARHGAP15, COLQ and FAM155A associate with diverticular disease and diverticulitis.10
298672002018Decreased expression of ARHGAP15 promotes the development of colorectal cancer through PTEN/AKT/FOXO1 axis.9
278626792017Forkhead box P3 regulates ARHGAP15 expression and affects migration of glioma cells through the Rac1 signaling pathway.7
295344682018ARHGAP15 in Human Breast Carcinoma: A Potent Tumor Suppressor Regulated by Androgens.1

Citation

Dessen P

ARHGAP15 (Rho GTPase activating protein 15)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43133/arhgap15