Identity
HGNC
LOCATION
16p12.1
LOCUSID
ALIAS
MST066,MST110,MSTP038,MSTP066,MSTP110,NADRIN,PP367,PP4534,RICH-1,RICH1,WBP15
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 55114
MIM: 608293
HGNC: 18239
Ensembl: ENSG00000140750
Variants:
dbSNP: 55114
ClinVar: 55114
TCGA: ENSG00000140750
COSMIC: ARHGAP17
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Tight junction | KEGG | ko04530 |
| Tight junction | KEGG | hsa04530 |
| Signal Transduction | REACTOME | R-HSA-162582 |
| Signaling by Rho GTPases | REACTOME | R-HSA-194315 |
| Rho GTPase cycle | REACTOME | R-HSA-194840 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36571786 | 2023 | ARHGAP17 regulates the spatiotemporal activity of Cdc42 at invadopodia. | 3 |
| 36571786 | 2023 | ARHGAP17 regulates the spatiotemporal activity of Cdc42 at invadopodia. | 3 |
| 35293764 | 2022 | ARHGAP17 enhances 5-Fluorouracil-induced apoptosis in colon cancer cells by suppressing Rac1. | 3 |
| 35293764 | 2022 | ARHGAP17 enhances 5-Fluorouracil-induced apoptosis in colon cancer cells by suppressing Rac1. | 3 |
| 32391922 | 2020 | ARHGAP17 inhibits pathological cyclic strain-induced apoptosis in human periodontal ligament fibroblasts via Rac1/Cdc42. | 4 |
| 32391922 | 2020 | ARHGAP17 inhibits pathological cyclic strain-induced apoptosis in human periodontal ligament fibroblasts via Rac1/Cdc42. | 4 |
| 30641218 | 2019 | ARHGAP17 suppresses tumor progression and up-regulates P21 and P27 expression via inhibiting PI3K/AKT signaling pathway in cervical cancer. | 20 |
| 30641218 | 2019 | ARHGAP17 suppresses tumor progression and up-regulates P21 and P27 expression via inhibiting PI3K/AKT signaling pathway in cervical cancer. | 20 |
| 29730655 | 2018 | Tumor Suppressive Role of ARHGAP17 in Colon Cancer Through Wnt/β-Catenin Signaling. | 9 |
| 29971782 | 2018 | Long isoform of VEGF stimulates cell migration of breast cancer by filopodia formation via NRP1/ARHGAP17/Cdc42 regulatory network. | 17 |
| 29730655 | 2018 | Tumor Suppressive Role of ARHGAP17 in Colon Cancer Through Wnt/β-Catenin Signaling. | 9 |
| 29971782 | 2018 | Long isoform of VEGF stimulates cell migration of breast cancer by filopodia formation via NRP1/ARHGAP17/Cdc42 regulatory network. | 17 |
| 26004135 | 2015 | Rich1 negatively regulates the epithelial cell cycle, proliferation and adhesion by CDC42/RAC1-PAK1-Erk1/2 pathway. | 14 |
| 26507661 | 2015 | Cyclic Nucleotide-dependent Protein Kinases Target ARHGAP17 and ARHGEF6 Complexes in Platelets. | 18 |
| 26004135 | 2015 | Rich1 negatively regulates the epithelial cell cycle, proliferation and adhesion by CDC42/RAC1-PAK1-Erk1/2 pathway. | 14 |
Citation
Dessen P
ARHGAP17 (Rho GTPase activating protein 17)
Atlas Genet Cytogenet Oncol Haematol. 2006-10-01
Online version: http://atlasgeneticsoncology.org/gene/43134/arhgap17
