ARHGAP24 (Rho GTPase activating protein 24)

2003-05-01  

Identity

HGNC
LOCATION
4q21.23
LOCUSID
ALIAS
FILGAP,RC-GAP72,RCGAP72,p73,p73RhoGAP
FUSION GENES

Other Information

Locus ID:

NCBI: 83478
MIM: 610586
HGNC: 25361
Ensembl: ENSG00000138639

Variants:

dbSNP: 83478
ClinVar: 83478
TCGA: ENSG00000138639
COSMIC: ARHGAP24

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000138639ENST00000264343Q8N264
ENSG00000138639ENST00000395183Q8N264
ENSG00000138639ENST00000395184Q8N264
ENSG00000138639ENST00000503995Q8N264
ENSG00000138639ENST00000509300D6RBC2
ENSG00000138639ENST00000512201D6RHH1
ENSG00000138639ENST00000514229D6RCP5

Expression (GTEx)

0
5
10
15
20
25

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
Rho GTPase cycleREACTOMER-HSA-194840

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
200620632010Several common variants modulate heart rate, PR interval and QRS duration.159
219269992011Mechanical strain in actin networks regulates FilGAP and integrin binding to filamin A.121
219119402011Arhgap24 inactivates Rac1 in mouse podocytes, and a mutant form is associated with familial focal segmental glomerulosclerosis.105
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
192939322009Molecular basis of filamin A-FilGAP interaction and its impairment in congenital disorders associated with filamin A mutations.37
191448232009The role of FilGAP-filamin A interactions in mechanoprotection.33
230974972012FilGAP, a Rho/Rho-associated protein kinase-regulated GTPase-activating protein for Rac, controls tumor cell migration.32
156111382005Characterization of a novel GTPase-activating protein associated with focal adhesions and the actin cytoskeleton.18
153029232004A vascular cell-restricted RhoGAP, p73RhoGAP, is a key regulator of angiogenesis.15
273850972016ARHGAP24 inhibits cell cycle progression, induces apoptosis and suppresses invasion in renal cell carcinoma.12

Citation

Dessen P

ARHGAP24 (Rho GTPase activating protein 24)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/695/arhgap24