ARHGAP35 (Rho GTPase activating protein 35)

2011-06-01  

Identity

HGNC
LOCATION
19q13.32
LOCUSID
ALIAS
GRF-1,GRLF1,P190-A,P190A,p190ARhoGAP,p190RhoGAP
FUSION GENES

Other Information

Locus ID:

NCBI: 2909
MIM: 605277
HGNC: 4591
Ensembl: ENSG00000160007

Variants:

dbSNP: 2909
ClinVar: 2909
TCGA: ENSG00000160007
COSMIC: ARHGAP35

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000160007ENST00000404338Q9NRY4
ENSG00000160007ENST00000614079Q9NRY4
ENSG00000160007ENST00000672722Q9NRY4

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Pathways

PathwaySourceExternal ID
Focal adhesionKEGGko04510
Leukocyte transendothelial migrationKEGGko04670
Regulation of actin cytoskeletonKEGGko04810
Focal adhesionKEGGhsa04510
Leukocyte transendothelial migrationKEGGhsa04670
Regulation of actin cytoskeletonKEGGhsa04810
Platelet activationKEGGhsa04611
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
Rho GTPase cycleREACTOMER-HSA-194840
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
Semaphorin interactionsREACTOMER-HSA-373755
Sema4D in semaphorin signalingREACTOMER-HSA-400685
Sema4D mediated inhibition of cell attachment and migrationREACTOMER-HSA-416550
Signaling by PTK6REACTOMER-HSA-8848021
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinasesREACTOMER-HSA-8849471

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
163083182006Suppression of RhoA activity by focal adhesion kinase-induced activation of p190RhoGAP: role in regulation of endothelial permeability.77
175627012007Angiopoietin-1 requires p190 RhoGAP to protect against vascular leakage in vivo.74
194358012009A FAK-p120RasGAP-p190RhoGAP complex regulates polarity in migrating cells.57
161889382005p190 Rho-GTPase activating protein associates with plexins and it is required for semaphorin signalling.38
188295322008Breast tumor kinase phosphorylates p190RhoGAP to regulate rho and ras and promote breast carcinoma growth, migration, and invasion.37
190860532009Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.34
192931502009Overexpression of E-cadherin on melanoma cells inhibits chemokine-promoted invasion involving p190RhoGAP/p120ctn-dependent inactivation of RhoA.22
206348912010Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia.18
186424452008Opposing roles of p190RhoGAP and Ect2 RhoGEF in regulating cytokinesis.17
205301972010The anaphase-promoting complex/cyclosome activator Cdh1 modulates Rho GTPase by targeting p190 RhoGAP for degradation.17

Citation

Dessen P

ARHGAP35 (Rho GTPase activating protein 35)

Atlas Genet Cytogenet Oncol Haematol. 2011-06-01

Online version: http://atlasgeneticsoncology.org/gene/52237/arhgap35