ARHGAP5 (Rho GTPase activating protein 5)

2009-03-01  

Identity

HGNC
ARHGAP5
LOCATION
14q12
LOCUSID
394
ALIAS
GFI2,RhoGAP5,p190-B,p190BRhoGAP
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 394
MIM: 602680
HGNC: 675
Ensembl: ENSG00000100852

Variants:

dbSNP: 394
ClinVar: 394
TCGA: ENSG00000100852
COSMIC: ARHGAP5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000100852ENST00000345122Q13017
ENSG00000100852ENST00000396582Q13017
ENSG00000100852ENST00000432921A0A0A0MSK6
ENSG00000100852ENST00000433497Q13017
ENSG00000100852ENST00000539826Q13017
ENSG00000100852ENST00000554090G3V360
ENSG00000100852ENST00000555814G3V5I7
ENSG00000100852ENST00000556191G3V444
ENSG00000100852ENST00000556611Q13017
ENSG00000100852ENST00000557643H0YK04

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Focal adhesionKEGGko04510
Leukocyte transendothelial migrationKEGGko04670
Focal adhesionKEGGhsa04510
Leukocyte transendothelial migrationKEGGhsa04670
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
Rho GTPase cycleREACTOMER-HSA-194840

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
234747612014Downregulation of miR-486-5p contributes to tumor progression and metastasis by targeting protumorigenic ARHGAP5 in lung cancer.97
146100592003p190RhoGAP is cell cycle regulated and affects cytokinesis.34
164697692006P190-B Rho GTPase-activating protein overexpression disrupts ductal morphogenesis and induces hyperplastic lesions in the developing mammary gland.26
259614342015MiR-744 functions as a proto-oncogene in nasopharyngeal carcinoma progression and metastasis via transcriptional control of ARHGAP5.24
198226672009Cdk5-dependent regulation of Rho activity, cytoskeletal contraction, and epithelial cell migration via suppression of Src and p190RhoGAP.17
243161342014Ionizing radiation-inducible miR-494 promotes glioma cell invasion through EGFR stabilization by targeting p190B rhoGAP.17
189966422009A novel amplification target, ARHGAP5, promotes cell spreading and migration by negatively regulating RhoA in Huh-7 hepatocellular carcinoma cells.13
302500202018SIRT1 suppresses the migration and invasion of gastric cancer by regulating ARHGAP5 expression.10
272310932016VEGF-A stimulates podosome-mediated collagen-IV proteolysis in microvascular endothelial cells.6
281007902017Genome-Wide Analysis in Brazilians Reveals Highly Differentiated Native American Genome Regions.6

Citation

Dessen P

ARHGAP5 (Rho GTPase activating protein 5)

Atlas Genet Cytogenet Oncol Haematol. 2009-03-01

Online version: http://atlasgeneticsoncology.org/gene/50686/arhgap5