Identity
HGNC
LOCATION
22q13.31
LOCUSID
ALIAS
BPGAP1,PP610
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 23779
MIM: 609405
HGNC: 677
Ensembl: ENSG00000241484
Variants:
dbSNP: 23779
ClinVar: 23779
TCGA: ENSG00000241484
COSMIC: ARHGAP8
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Signal Transduction | REACTOME | R-HSA-162582 |
| Signaling by Rho GTPases | REACTOME | R-HSA-194315 |
| Rho GTPase cycle | REACTOME | R-HSA-194840 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36598812 | 2023 | The scaffold RhoGAP protein ARHGAP8/BPGAP1 synchronizes Rac and Rho signaling to facilitate cell migration. | 4 |
| 36598812 | 2023 | The scaffold RhoGAP protein ARHGAP8/BPGAP1 synchronizes Rac and Rho signaling to facilitate cell migration. | 4 |
| 29391396 | 2018 | Bipolar disorder with binge eating behavior: a genome-wide association study implicates PRR5-ARHGAP8. | 6 |
| 29391396 | 2018 | Bipolar disorder with binge eating behavior: a genome-wide association study implicates PRR5-ARHGAP8. | 6 |
| 28092672 | 2017 | BPGAP1 spatially integrates JNK/ERK signaling crosstalk in oncogenesis. | 8 |
| 28092672 | 2017 | BPGAP1 spatially integrates JNK/ERK signaling crosstalk in oncogenesis. | 8 |
| 20179103 | 2010 | Active Mek2 as a regulatory scaffold that promotes Pin1 binding to BPGAP1 to suppress BPGAP1-induced acute Erk activation and cell migration. | 11 |
| 20628086 | 2010 | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. | 15 |
| 20179103 | 2010 | Active Mek2 as a regulatory scaffold that promotes Pin1 binding to BPGAP1 to suppress BPGAP1-induced acute Erk activation and cell migration. | 11 |
| 20628086 | 2010 | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. | 15 |
| 19913121 | 2009 | Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. | 105 |
| 19913121 | 2009 | Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. | 105 |
| 15944398 | 2005 | Activation of EGF receptor endocytosis and ERK1/2 signaling by BPGAP1 requires direct interaction with EEN/endophilin II and a functional RhoGAP domain. | 15 |
| 15944398 | 2005 | Activation of EGF receptor endocytosis and ERK1/2 signaling by BPGAP1 requires direct interaction with EEN/endophilin II and a functional RhoGAP domain. | 15 |
| 15064355 | 2004 | BPGAP1 interacts with cortactin and facilitates its translocation to cell periphery for enhanced cell migration. | 17 |
Citation
Dessen P
ARHGAP8 (Rho GTPase activating protein 8)
Atlas Genet Cytogenet Oncol Haematol. 2006-10-01
Online version: http://atlasgeneticsoncology.org/gene/43142/arhgap8
