ARHGAP8 (Rho GTPase activating protein 8)

2006-10-01  

Identity

HGNC
LOCATION
22q13.31
LOCUSID
ALIAS
BPGAP1,PP610
FUSION GENES

Other Information

Locus ID:

NCBI: 23779
MIM: 609405
HGNC: 677
Ensembl: ENSG00000241484

Variants:

dbSNP: 23779
ClinVar: 23779
TCGA: ENSG00000241484
COSMIC: ARHGAP8

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000241484ENST00000336963P85298
ENSG00000241484ENST00000356099P85298
ENSG00000241484ENST00000389772F8W6F4
ENSG00000241484ENST00000389774P85298
ENSG00000241484ENST00000396119B1AHF8
ENSG00000241484ENST00000412433B1AHC2
ENSG00000241484ENST00000447333F8WCV8

Expression (GTEx)

0
5
10
15
20
25
30
35
40

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
Rho GTPase cycleREACTOMER-HSA-194840

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
152258762004ARHGAP8 is a novel member of the RHOGAP family related to ARHGAP1/CDC42GAP/p50RHOGAP: mutation and expression analyses in colorectal and breast cancers.18
129444072003Concerted regulation of cell dynamics by BNIP-2 and Cdc42GAP homology/Sec14p-like, proline-rich, and GTPase-activating protein domains of a novel Rho GTPase-activating protein, BPGAP1.15
159443982005Activation of EGF receptor endocytosis and ERK1/2 signaling by BPGAP1 requires direct interaction with EEN/endophilin II and a functional RhoGAP domain.12
150643552004BPGAP1 interacts with cortactin and facilitates its translocation to cell periphery for enhanced cell migration.11
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11
201791032010Active Mek2 as a regulatory scaffold that promotes Pin1 binding to BPGAP1 to suppress BPGAP1-induced acute Erk activation and cell migration.7
293913962018Bipolar disorder with binge eating behavior: a genome-wide association study implicates PRR5-ARHGAP8.4
125595662003Identification and characterization of a gene encoding a putative mouse Rho GTPase activating protein gene 8, Arhgap8.2
155069812004Filling the GAPs in cell dynamics control: BPGAP1 promotes cortactin translocation to the cell periphery for enhanced cell migration.2

Citation

Dessen P

ARHGAP8 (Rho GTPase activating protein 8)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43142/arhgap8