ARHGDIB (Rho GDP dissociation inhibitor beta)

2007-12-01  

Identity

HGNC
LOCATION
12p12.3
LOCUSID
ALIAS
D4,GDIA2,GDID4,LYGDI,Ly-GDI,RAP1GN1,RhoGDI2
FUSION GENES

Other Information

Locus ID:

NCBI: 397
MIM: 602843
HGNC: 679
Ensembl: ENSG00000111348

Variants:

dbSNP: 397
ClinVar: 397
TCGA: ENSG00000111348
COSMIC: ARHGDIB

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000111348ENST00000228945P52566
ENSG00000111348ENST00000228945A0A024RAS5
ENSG00000111348ENST00000536592H0YGX7
ENSG00000111348ENST00000541380F5H6Q0
ENSG00000111348ENST00000541546P52566
ENSG00000111348ENST00000541546A0A024RAS5
ENSG00000111348ENST00000541644P52566
ENSG00000111348ENST00000541644A0A024RAS5
ENSG00000111348ENST00000542276F5H2R5
ENSG00000111348ENST00000545895F5H3P3

Expression (GTEx)

0
500
1000
1500

Pathways

PathwaySourceExternal ID
Neurotrophin signaling pathwayKEGGko04722
Neurotrophin signaling pathwayKEGGhsa04722
Vasopressin-regulated water reabsorptionKEGGko04962
Vasopressin-regulated water reabsorptionKEGGhsa04962
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
Rho GTPase cycleREACTOMER-HSA-194840

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
224065352012RhoGDI2 suppresses lung metastasis in mice by reducing tumor versican expression and macrophage infiltration.56
151730882004Reduced expression of metastasis suppressor RhoGDI2 is associated with decreased survival for patients with bladder cancer.54
195092382009Consensus transcriptome signature of perineural invasion in pancreatic carcinoma.35
193217442009Src phosphorylation of RhoGDI2 regulates its metastasis suppressor function.33
186766802008Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.32
192763872009Rho GDP dissociation inhibitor 2 suppresses metastasis via unconventional regulation of RhoGTPases.32
227773552013Rictor regulates cell migration by suppressing RhoGDI2.31
193517662009RhoGDI2 expression is associated with tumor growth and malignant progression of gastric cancer.27
196921682010Genetic susceptibility to distinct bladder cancer subphenotypes.25
192699692009Silencing of D4-GDI inhibits growth and invasive behavior in MDA-MB-231 cells by activation of Rac-dependent p38 and JNK signaling.23

Citation

Dessen P

ARHGDIB (Rho GDP dissociation inhibitor beta)

Atlas Genet Cytogenet Oncol Haematol. 2007-12-01

Online version: http://atlasgeneticsoncology.org/gene/49851/arhgdib