ARHGEF11 (Rho guanine nucleotide exchange factor 11)

2006-10-01  

Identity

HGNC
LOCATION
1q23.1
LOCUSID
ALIAS
GTRAP48,PDZ-RHOGEF
FUSION GENES

Other Information

Locus ID:

NCBI: 9826
MIM: 605708
HGNC: 14580
Ensembl: ENSG00000132694

Variants:

dbSNP: 9826
ClinVar: 9826
TCGA: ENSG00000132694
COSMIC: ARHGEF11

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000132694ENST00000361409O15085
ENSG00000132694ENST00000368194O15085

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
Pathways in cancerKEGGhsa05200
Vascular smooth muscle contractionKEGGhsa04270
Vascular smooth muscle contractionKEGGko04270
Signal TransductionREACTOMER-HSA-162582
Signalling by NGFREACTOMER-HSA-166520
p75 NTR receptor-mediated signallingREACTOMER-HSA-193704
Cell death signalling via NRAGE, NRIF and NADEREACTOMER-HSA-204998
NRAGE signals death through JNKREACTOMER-HSA-193648
Signaling by Rho GTPasesREACTOMER-HSA-194315
Rho GTPase cycleREACTOMER-HSA-194840
Signaling by GPCRREACTOMER-HSA-372790
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (12/13) signalling eventsREACTOMER-HSA-416482
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
Semaphorin interactionsREACTOMER-HSA-373755
Sema4D in semaphorin signalingREACTOMER-HSA-400685
Sema4D induced cell migration and growth-cone collapseREACTOMER-HSA-416572

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
121834582002Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF.79
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
180869132007PDZRhoGEF and myosin II localize RhoA activity to the back of polarizing neutrophil-like cells.36
214544922011Mechanistic insights into specificity, activity, and regulatory elements of the regulator of G-protein signaling (RGS)-containing Rho-specific guanine nucleotide exchange factors (GEFs) p115, PDZ-RhoGEF (PRG), and leukemia-associated RhoGEF (LARG).31
197593752009PYK2/PDZ-RhoGEF links Ca2+ signaling to RhoA.30
151430722004Thrombin and lysophosphatidic acid receptors utilize distinct rhoGEFs in prostate cancer cells.28
146253122004Direct interaction of p21-activated kinase 4 with PDZ-RhoGEF, a G protein-linked Rho guanine exchange factor.25
147427192004Identification of a novel sequence in PDZ-RhoGEF that mediates interaction with the actin cytoskeleton.23
206137662010Genome-wide association study to identify genetic variants present in Japanese patients harboring intracranial aneurysms.22
194601552009On the mechanism of autoinhibition of the RhoA-specific nucleotide exchange factor PDZRhoGEF.19

Citation

Dessen P

ARHGEF11 (Rho guanine nucleotide exchange factor 11)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43145/arhgef11