ARHGEF15 (Rho guanine nucleotide exchange factor 15)

2006-10-01  

Identity

HGNC
ARHGEF15
LOCATION
17p13.1
LOCUSID
22899
ALIAS
ARGEF15,E5,Ephexin5,Vsm-RhoGEF
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 22899
MIM: 608504
HGNC: 15590
Ensembl: ENSG00000198844

Variants:

dbSNP: 22899
ClinVar: 22899
TCGA: ENSG00000198844
COSMIC: ARHGEF15

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000198844ENST00000361926O94989
ENSG00000198844ENST00000361926A0A0S2Z547
ENSG00000198844ENST00000421050O94989
ENSG00000198844ENST00000421050A0A0S2Z547
ENSG00000198844ENST00000579439J3QS60
ENSG00000198844ENST00000581809J3QQS4
ENSG00000198844ENST00000583529J3KT46
ENSG00000198844ENST00000647883A0A3B3IUF8

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signalling by NGFREACTOMER-HSA-166520
p75 NTR receptor-mediated signallingREACTOMER-HSA-193704
Cell death signalling via NRAGE, NRIF and NADEREACTOMER-HSA-204998
NRAGE signals death through JNKREACTOMER-HSA-193648
Signaling by Rho GTPasesREACTOMER-HSA-194315
Rho GTPase cycleREACTOMER-HSA-194840
Signaling by GPCRREACTOMER-HSA-372790
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (12/13) signalling eventsREACTOMER-HSA-416482

References

Pubmed IDYearTitleCitations
283462272017Reducing expression of synapse-restricting protein Ephexin5 ameliorates Alzheimer's-like impairment in mice.12
283462272017Reducing expression of synapse-restricting protein Ephexin5 ameliorates Alzheimer's-like impairment in mice.12
271459642016ARHGEF15 overexpression worsens the prognosis in patients with pancreatic ductal adenocarcinoma through enhancing the motility and proliferative activity of the cancer cells.7
271459642016ARHGEF15 overexpression worsens the prognosis in patients with pancreatic ductal adenocarcinoma through enhancing the motility and proliferative activity of the cancer cells.7
230292802012Arhgef15 promotes retinal angiogenesis by mediating VEGF-induced Cdc42 activation and potentiating RhoJ inactivation in endothelial cells.29
230292802012Arhgef15 promotes retinal angiogenesis by mediating VEGF-induced Cdc42 activation and potentiating RhoJ inactivation in endothelial cells.29
199110112010Mutation of ARHGAP9 in patients with coronary spastic angina.0
199110112010Mutation of ARHGAP9 in patients with coronary spastic angina.0
127755842003EphA4-mediated Rho activation via Vsm-RhoGEF expressed specifically in vascular smooth muscle cells.49
127755842003EphA4-mediated Rho activation via Vsm-RhoGEF expressed specifically in vascular smooth muscle cells.49

Citation

Dessen P

ARHGEF15 (Rho guanine nucleotide exchange factor 15)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/42989/arhgef15