ARHGEF15 (Rho guanine nucleotide exchange factor 15)

2006-10-01  

Identity

HGNC
LOCATION
17p13.1
LOCUSID
ALIAS
ARGEF15,E5,Ephexin5,Vsm-RhoGEF
FUSION GENES

Other Information

Locus ID:

NCBI: 22899
MIM: 608504
HGNC: 15590
Ensembl: ENSG00000198844

Variants:

dbSNP: 22899
ClinVar: 22899
TCGA: ENSG00000198844
COSMIC: ARHGEF15

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000198844ENST00000361926O94989
ENSG00000198844ENST00000361926A0A0S2Z547
ENSG00000198844ENST00000421050O94989
ENSG00000198844ENST00000421050A0A0S2Z547
ENSG00000198844ENST00000579439J3QS60
ENSG00000198844ENST00000581809J3QQS4
ENSG00000198844ENST00000583529J3KT46
ENSG00000198844ENST00000647883A0A3B3IUF8

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signalling by NGFREACTOMER-HSA-166520
p75 NTR receptor-mediated signallingREACTOMER-HSA-193704
Cell death signalling via NRAGE, NRIF and NADEREACTOMER-HSA-204998
NRAGE signals death through JNKREACTOMER-HSA-193648
Signaling by Rho GTPasesREACTOMER-HSA-194315
Rho GTPase cycleREACTOMER-HSA-194840
Signaling by GPCRREACTOMER-HSA-372790
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (12/13) signalling eventsREACTOMER-HSA-416482

References

Pubmed IDYearTitleCitations
127755842003EphA4-mediated Rho activation via Vsm-RhoGEF expressed specifically in vascular smooth muscle cells.37
230292802012Arhgef15 promotes retinal angiogenesis by mediating VEGF-induced Cdc42 activation and potentiating RhoJ inactivation in endothelial cells.18
283462272017Reducing expression of synapse-restricting protein Ephexin5 ameliorates Alzheimer's-like impairment in mice.8
199110112010Mutation of ARHGAP9 in patients with coronary spastic angina.5
271459642016ARHGEF15 overexpression worsens the prognosis in patients with pancreatic ductal adenocarcinoma through enhancing the motility and proliferative activity of the cancer cells.4

Citation

Dessen P

ARHGEF15 (Rho guanine nucleotide exchange factor 15)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/42989/arhgef15