ARHGEF3 (Rho guanine nucleotide exchange factor 3)

2006-10-01 Affiliation

Identity

HGNC

ARHGEF3

LOCATION

3p14.3

LOCUSID

50650

ALIAS

GEF3,STA3,XPLN

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 50650
MIM: 612115
HGNC: 683
Ensembl: ENSG00000163947

Variants:

dbSNP: 50650
ClinVar: 50650
TCGA: ENSG00000163947
COSMIC: ARHGEF3

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000163947	ENST00000296315	Q9NR81
ENSG00000163947	ENST00000338458	Q9NR81
ENSG00000163947	ENST00000413728	Q9NR81
ENSG00000163947	ENST00000465659	H7C4P0
ENSG00000163947	ENST00000468466	C9J5K8
ENSG00000163947	ENST00000468727	C9J609
ENSG00000163947	ENST00000473779	C9JNF2
ENSG00000163947	ENST00000477833	F8WC29
ENSG00000163947	ENST00000486829	F8WDB7
ENSG00000163947	ENST00000495373	C9J586
ENSG00000163947	ENST00000496106	E9PG37
ENSG00000163947	ENST00000497267	E7EU49

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Signal Transduction	REACTOME	R-HSA-162582
Signalling by NGF	REACTOME	R-HSA-166520
p75 NTR receptor-mediated signalling	REACTOME	R-HSA-193704
Cell death signalling via NRAGE, NRIF and NADE	REACTOME	R-HSA-204998
NRAGE signals death through JNK	REACTOME	R-HSA-193648
Signaling by Rho GTPases	REACTOME	R-HSA-194315
Rho GTPase cycle	REACTOME	R-HSA-194840
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR downstream signaling	REACTOME	R-HSA-388396
G alpha (12/13) signalling events	REACTOME	R-HSA-416482

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
20379614	2010	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.	62
12221096	2002	XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC.	54
19110211	2009	A genome-wide association study identifies three loci associated with mean platelet volume.	41
29998287	2018	DNA Methylation Signatures of Depressive Symptoms in Middle-aged and Elderly Persons: Meta-analysis of Multiethnic Epigenome-wide Studies.	15
18499081	2008	Identification of a role for the ARHGEF3 gene in postmenopausal osteoporosis.	13
18499081	2008	Identification of a role for the ARHGEF3 gene in postmenopausal osteoporosis.	13
24043828	2013	XPLN is an endogenous inhibitor of mTORC2.	13
24840563	2014	Influence of ARHGEF3 and RHOA knockdown on ACTA2 and other genes in osteoblasts and osteoclasts.	11
19427924	2009	Further genetic evidence suggesting a role for the RhoGTPase-RhoGEF pathway in osteoporosis.	7
25494542	2015	ARHGEF3 controls HDACi-induced differentiation via RhoA-dependent pathways in acute myeloid leukemias.	7

Citation

Dessen P

ARHGEF3 (Rho guanine nucleotide exchange factor 3)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43151/arhgef3