Identity
HGNC
LOCATION
2q21.1
LOCUSID
ALIAS
ASEF,ASEF1,GEF4,SMIM39,STM6
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 50649
MIM: 605216
HGNC: 684
Ensembl: ENSG00000136002
Variants:
dbSNP: 50649
ClinVar: 50649
TCGA: ENSG00000136002
COSMIC: ARHGEF4
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 33670371 | 2021 | Conformational Selection Mechanism Provides Structural Insights into the Optimization of APC-Asef Inhibitors. | 7 |
| 33670371 | 2021 | Conformational Selection Mechanism Provides Structural Insights into the Optimization of APC-Asef Inhibitors. | 7 |
| 29866653 | 2018 | Truncated Adenomatous Polyposis Coli Mutation Induces Asef-Activated Golgi Fragmentation. | 6 |
| 30226582 | 2018 | ARHGEF4 predicts poor prognosis and promotes cell invasion by influencing ERK1/2 and GSK-3α/β signaling in pancreatic cancer. | 7 |
| 29866653 | 2018 | Truncated Adenomatous Polyposis Coli Mutation Induces Asef-Activated Golgi Fragmentation. | 6 |
| 30226582 | 2018 | ARHGEF4 predicts poor prognosis and promotes cell invasion by influencing ERK1/2 and GSK-3α/β signaling in pancreatic cancer. | 7 |
| 28428959 | 2017 | Copy Number Variations in Candidate Genes and Intergenic Regions Affect Body Mass Index and Abdominal Obesity in Mexican Children. | 5 |
| 28428959 | 2017 | Copy Number Variations in Candidate Genes and Intergenic Regions Affect Body Mass Index and Abdominal Obesity in Mexican Children. | 5 |
| 26929985 | 2016 | Quantitative genome-wide methylation analysis of high-grade non-muscle invasive bladder cancer. | 22 |
| 26929985 | 2016 | Quantitative genome-wide methylation analysis of high-grade non-muscle invasive bladder cancer. | 22 |
| 25539852 | 2015 | Asef mediates HGF protective effects against LPS-induced lung injury and endothelial barrier dysfunction. | 24 |
| 25539852 | 2015 | Asef mediates HGF protective effects against LPS-induced lung injury and endothelial barrier dysfunction. | 24 |
| 25101856 | 2014 | Hepatocyte growth factor triggers distinct mechanisms of Asef and Tiam1 activation to induce endothelial barrier enhancement. | 7 |
| 25101856 | 2014 | Hepatocyte growth factor triggers distinct mechanisms of Asef and Tiam1 activation to induce endothelial barrier enhancement. | 7 |
| 23941980 | 2013 | Association of Asef and Cdc42 expression to tubular injury in diseased human kidney. | 3 |
Citation
Dessen P
ARHGEF4 (Rho guanine nucleotide exchange factor 4)
Atlas Genet Cytogenet Oncol Haematol. 2003-02-01
Online version: http://atlasgeneticsoncology.org/gene/700/arhgef4
