ARHGEF7 (Rho guanine nucleotide exchange factor 7)

2006-10-01  

Identity

HGNC
LOCATION
13q34
LOCUSID
ALIAS
BETA-PIX,COOL-1,COOL1,Nbla10314,P50,P50BP,P85,P85COOL1,P85SPR,PAK3,PIXB
FUSION GENES

Other Information

Locus ID:

NCBI: 8874
MIM: 605477
HGNC: 15607
Ensembl: ENSG00000102606

Variants:

dbSNP: 8874
ClinVar: 8874
TCGA: ENSG00000102606
COSMIC: ARHGEF7

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000102606ENST00000218789B1ALK7
ENSG00000102606ENST00000317133Q14155
ENSG00000102606ENST00000375723Q14155
ENSG00000102606ENST00000375736Q14155
ENSG00000102606ENST00000375736A0A024RDY9
ENSG00000102606ENST00000375739Q14155
ENSG00000102606ENST00000375741Q14155
ENSG00000102606ENST00000426073Q14155
ENSG00000102606ENST00000426073A0A024RDY9
ENSG00000102606ENST00000426768E7ENL8
ENSG00000102606ENST00000449979B1ANY6
ENSG00000102606ENST00000466143E7EUY6
ENSG00000102606ENST00000467053C9JDI6
ENSG00000102606ENST00000469877E7EU80
ENSG00000102606ENST00000478679E9PDQ5
ENSG00000102606ENST00000491775C9JAD7
ENSG00000102606ENST00000544132F6SJA5
ENSG00000102606ENST00000646102A0A2R8YG42

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
Regulation of actin cytoskeletonKEGGko04810
Regulation of actin cytoskeletonKEGGhsa04810
Signal TransductionREACTOMER-HSA-162582
Signaling by EGFRREACTOMER-HSA-177929
EGFR downregulationREACTOMER-HSA-182971
Signalling by NGFREACTOMER-HSA-166520
p75 NTR receptor-mediated signallingREACTOMER-HSA-193704
Cell death signalling via NRAGE, NRIF and NADEREACTOMER-HSA-204998
NRAGE signals death through JNKREACTOMER-HSA-193648
Signaling by Rho GTPasesREACTOMER-HSA-194315
Rho GTPase cycleREACTOMER-HSA-194840
Signaling by GPCRREACTOMER-HSA-372790
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (12/13) signalling eventsREACTOMER-HSA-416482
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
EPH-Ephrin signalingREACTOMER-HSA-2682334
Ephrin signalingREACTOMER-HSA-3928664

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
214231762011Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation.234
164928082006Targeting and activation of Rac1 are mediated by the exchange factor beta-Pix.112
152127612004The GIT/PIX complex: an oligomeric assembly of GIT family ARF GTPase-activating proteins and PIX family Rac1/Cdc42 guanine nucleotide exchange factors.57
203954462010Podocalyxin EBP50 ezrin molecular complex enhances the metastatic potential of renal cell carcinoma through recruiting Rac1 guanine nucleotide exchange factor ARHGEF7.44
158643112005Dynamic recruitment of PAK1 to the immunological synapse is mediated by PIX independently of SLP-76 and Vav1.41
172194082007Tiam1 and betaPIX mediate Rac-dependent endothelial barrier protective response to oxidized phospholipids.38
255005332014Phosphorylation of LRRK2 by casein kinase 1α regulates trans-Golgi clustering via differential interaction with ARHGEF7.36
251509782014An extracellular-matrix-specific GEF-GAP interaction regulates Rho GTPase crosstalk for 3D collagen migration.33
252847832014GIT1 and βPIX are essential for GABA(A) receptor synaptic stability and inhibitory neurotransmission.29
181607192008Protein kinase A-dependent phosphorylation modulates beta1Pix guanine nucleotide exchange factor activity through 14-3-3beta binding.28

Citation

Dessen P

ARHGEF7 (Rho guanine nucleotide exchange factor 7)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43153/arhgef7