ARID3A (AT-rich interaction domain 3A)

2007-02-01  

Identity

HGNC
LOCATION
19p13.3
LOCUSID
ALIAS
BRIGHT,DRIL1,DRIL3,E2FBP1
FUSION GENES

Other Information

Locus ID:

NCBI: 1820
MIM: 603265
HGNC: 3031
Ensembl: ENSG00000116017

Variants:

dbSNP: 1820
ClinVar: 1820
TCGA: ENSG00000116017
COSMIC: ARID3A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000116017ENST00000263620Q99856
ENSG00000116017ENST00000457152H0YFY1
ENSG00000116017ENST00000587532K7EJ04

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
TP53 Regulates Transcription of Cell Cycle GenesREACTOMER-HSA-6791312
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle ArrestREACTOMER-HSA-6804116

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
118129992002A functional screen identifies hDRIL1 as an oncogene that rescues RAS-induced senescence.33
167383372006Induction of immunoglobulin heavy-chain transcription through the transcription factor Bright requires TFII-I.27
192141912009Signalling of the BCR is regulated by a lipid rafts-localised transcription factor, Bright.21
206809602010Loss of Bright/ARID3a function promotes developmental plasticity.21
173861012007Bright/ARID3A contributes to chromatin accessibility of the immunoglobulin heavy chain enhancer.20
224697802012B-cell regulator of immunoglobulin heavy-chain transcription (Bright)/ARID3a is a direct target of the oncomir microRNA-125b in progenitor B-cells.18
126922632003E2FBP1/DRIL1, an AT-rich interaction domain-family transcription factor, is regulated by p53.16
121937172002High frequency of matrix attachment regions and cut-like protein x/CCAAT-displacement protein and B cell regulator of IgH transcription binding sites flanking Ig V region genes.14
152033192004The transcription factor, Bright, is not expressed in all human B lymphocyte subpopulations.14

Citation

Dessen P

ARID3A (AT-rich interaction domain 3A)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45573/arid3a