Atlas of Genetics and Cytogenetics in Oncology and Haematology

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ARIH2 (ariadne RBR E3 ubiquitin protein ligase 2)

Identity

Alias_namesariadne (Drosophila) homolog 2
ariadne homolog 2 (Drosophila)
Alias_symbol (synonym)TRIAD1
Other aliasARI2
HGNC (Hugo) ARIH2
LocusID (NCBI) 10425
Atlas_Id 54134
Location 3p21.31  [Link to chromosome band 3p21]
Location_base_pair Starts at 48918820 and ends at 48985538 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ARIH2 (3p21.31) / ARIH2 (3p21.31)ARIH2 (3p21.31) / CAMP (3p21.31)ARIH2 (3p21.31) / DHX30 (3p21.31)
ARIH2 (3p21.31) / RHOA (3p21.31)ARIH2 (3p21.31) / SLC25A20 (3p21.31)ARIH2 (3p21.31) / TOX3 (16q12.1)
ARIH2 (3p21.31) / TRIO (5p15.2)HLA-DRB1 (6p21.32) / ARIH2 (3p21.31)NCL (2q37.1) / ARIH2 (3p21.31)
PAG1 (8q21.13) / ARIH2 (3p21.31)RBM6 (3p21.31) / ARIH2 (3p21.31)TCTA (3p21.31) / ARIH2 (3p21.31)
TMEM119 (12q23.3) / ARIH2 (3p21.31)TOX3 (16q12.1) / ARIH2 (3p21.31)ARIH2 3p21.31 / CAMP 3p21.31
ARIH2 3p21.31 / DHX30 3p21.31ARIH2 3p21.31 / RHOA 3p21.31ARIH2 3p21.31 / SLC25A20 3p21.31
ARIH2 3p21.31 / TRIO 5p15.2RBM6 3p21.31 / ARIH2 3p21.31TCTA 3p21.31 / ARIH2 3p21.31

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 8 ]
  ARIH2/CAMP (3p21)
ARIH2/DHX30 (3p21)
ARIH2/RHOA (3p21)
ARIH2/SLC25A20 (3p21)
RBM6/ARIH2 (3p21)
TCTA/ARIH2 (3p21)
t(3;5)(p21;p15) ARIH2/TRIO
t(3;12)(p21;q23) TMEM119/ARIH2

External links

Nomenclature
HGNC (Hugo)ARIH2   690
Cards
Entrez_Gene (NCBI)ARIH2  10425  ariadne RBR E3 ubiquitin protein ligase 2
AliasesARI2; TRIAD1
GeneCards (Weizmann)ARIH2
Ensembl hg19 (Hinxton)ENSG00000177479 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000177479 [Gene_View]  ENSG00000177479 [Sequence]  chr3:48918820-48985538 [Contig_View]  ARIH2 [Vega]
ICGC DataPortalENSG00000177479
TCGA cBioPortalARIH2
AceView (NCBI)ARIH2
Genatlas (Paris)ARIH2
WikiGenes10425
SOURCE (Princeton)ARIH2
Genetics Home Reference (NIH)ARIH2
Genomic and cartography
GoldenPath hg38 (UCSC)ARIH2  -     chr3:48918820-48985538 +  3p21.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ARIH2  -     3p21.31   [Description]    (hg19-Feb_2009)
GoldenPathARIH2 - 3p21.31 [CytoView hg19]  ARIH2 - 3p21.31 [CytoView hg38]
ImmunoBaseENSG00000177479
Mapping of homologs : NCBIARIH2 [Mapview hg19]  ARIH2 [Mapview hg38]
OMIM605615   
Gene and transcription
Genbank (Entrez)AB208857 AF099149 AF099150 AF099151 AF099152
RefSeq transcript (Entrez)NM_001317333 NM_001317334 NM_001349209 NM_001349210 NM_001349211 NM_001349212 NM_001349213 NM_001349214 NM_001349215 NM_001349216 NM_001349217 NM_001349218 NM_001349219 NM_001349220 NM_001349221 NM_001349222 NM_001349223 NM_001349224 NM_001349225 NM_001349226 NM_001349227 NM_001349228 NM_001349229 NM_001349230 NM_006321
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ARIH2
Cluster EST : UnigeneHs.633601 [ NCBI ]
CGAP (NCI)Hs.633601
Alternative Splicing GalleryENSG00000177479
Gene ExpressionARIH2 [ NCBI-GEO ]   ARIH2 [ EBI - ARRAY_EXPRESS ]   ARIH2 [ SEEK ]   ARIH2 [ MEM ]
Gene Expression Viewer (FireBrowse)ARIH2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10425
GTEX Portal (Tissue expression)ARIH2
Human Protein AtlasENSG00000177479-ARIH2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO95376   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO95376  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO95376
Splice isoforms : SwissVarO95376
PhosPhoSitePlusO95376
Domaine pattern : Prosite (Expaxy)ZF_RING_1 (PS00518)    ZF_RING_2 (PS50089)   
Domains : Interpro (EBI)Ariadne-2    E3_UB_ligase_RBR    IBR_dom    Znf_RING    Znf_RING/FYVE/PHD    Znf_RING_CS   
Domain families : Pfam (Sanger)IBR (PF01485)   
Domain families : Pfam (NCBI)pfam01485   
Domain families : Smart (EMBL)IBR (SM00647)  RING (SM00184)  
Conserved Domain (NCBI)ARIH2
DMDM Disease mutations10425
Blocks (Seattle)ARIH2
SuperfamilyO95376
Human Protein Atlas [tissue]ENSG00000177479-ARIH2 [tissue]
Peptide AtlasO95376
HPRD09286
IPIIPI00007304   IPI00902655   IPI00792023   IPI00790910   IPI00924879   IPI00926739   IPI00926138   IPI00926387   
Protein Interaction databases
DIP (DOE-UCLA)O95376
IntAct (EBI)O95376
FunCoupENSG00000177479
BioGRIDARIH2
STRING (EMBL)ARIH2
ZODIACARIH2
Ontologies - Pathways
QuickGOO95376
Ontology : AmiGOubiquitin ligase complex  protein polyubiquitination  protein polyubiquitination  ubiquitin-protein transferase activity  protein binding  nucleus  nucleoplasm  cytoplasm  cytoplasm  ubiquitin-dependent protein catabolic process  ubiquitin-dependent protein catabolic process  multicellular organism development  zinc ion binding  protein ubiquitination  Cul5-RING ubiquitin ligase complex  ubiquitin conjugating enzyme binding  ubiquitin conjugating enzyme binding  positive regulation of proteasomal ubiquitin-dependent protein catabolic process  developmental cell growth  ubiquitin protein ligase activity  protein K63-linked ubiquitination  protein K48-linked ubiquitination  hematopoietic stem cell proliferation  positive regulation of protein targeting to mitochondrion  
Ontology : EGO-EBIubiquitin ligase complex  protein polyubiquitination  protein polyubiquitination  ubiquitin-protein transferase activity  protein binding  nucleus  nucleoplasm  cytoplasm  cytoplasm  ubiquitin-dependent protein catabolic process  ubiquitin-dependent protein catabolic process  multicellular organism development  zinc ion binding  protein ubiquitination  Cul5-RING ubiquitin ligase complex  ubiquitin conjugating enzyme binding  ubiquitin conjugating enzyme binding  positive regulation of proteasomal ubiquitin-dependent protein catabolic process  developmental cell growth  ubiquitin protein ligase activity  protein K63-linked ubiquitination  protein K48-linked ubiquitination  hematopoietic stem cell proliferation  positive regulation of protein targeting to mitochondrion  
NDEx NetworkARIH2
Atlas of Cancer Signalling NetworkARIH2
Wikipedia pathwaysARIH2
Orthology - Evolution
OrthoDB10425
GeneTree (enSembl)ENSG00000177479
Phylogenetic Trees/Animal Genes : TreeFamARIH2
HOGENOMO95376
Homologs : HomoloGeneARIH2
Homology/Alignments : Family Browser (UCSC)ARIH2
Gene fusions - Rearrangements
Fusion : MitelmanARIH2/CAMP [3p21.31/3p21.31]  
Fusion : MitelmanARIH2/DHX30 [3p21.31/3p21.31]  [t(3;3)(p21;p21)]  
Fusion : MitelmanARIH2/RHOA [3p21.31/3p21.31]  [t(3;3)(p21;p21)]  
Fusion : MitelmanARIH2/SLC25A20 [3p21.31/3p21.31]  [t(3;3)(p21;p21)]  
Fusion : MitelmanARIH2/TRIO [3p21.31/5p15.2]  [t(3;5)(p21;p15)]  
Fusion : MitelmanRBM6/ARIH2 [3p21.31/3p21.31]  [t(3;3)(p21;p21)]  
Fusion : MitelmanTCTA/ARIH2 [3p21.31/3p21.31]  [t(3;3)(p21;p21)]  
Fusion : MitelmanTMEM119/ARIH2 [12q23.3/3p21.31]  [t(3;12)(p21;q23)]  
Fusion PortalARIH2 3p21.31 CAMP 3p21.31 GBM
Fusion PortalARIH2 3p21.31 DHX30 3p21.31 BRCA
Fusion PortalARIH2 3p21.31 RHOA 3p21.31 BLCA
Fusion PortalARIH2 3p21.31 SLC25A20 3p21.31 BRCA
Fusion PortalARIH2 3p21.31 TRIO 5p15.2 HNSC
Fusion PortalRBM6 3p21.31 ARIH2 3p21.31 BRCA
Fusion PortalTCTA 3p21.31 ARIH2 3p21.31 BRCA
Fusion : QuiverARIH2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerARIH2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ARIH2
dbVarARIH2
ClinVarARIH2
1000_GenomesARIH2 
Exome Variant ServerARIH2
ExAC (Exome Aggregation Consortium)ENSG00000177479
GNOMAD BrowserENSG00000177479
Varsome BrowserARIH2
Genetic variants : HAPMAP10425
Genomic Variants (DGV)ARIH2 [DGVbeta]
DECIPHERARIH2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisARIH2 
Mutations
ICGC Data PortalARIH2 
TCGA Data PortalARIH2 
Broad Tumor PortalARIH2
OASIS PortalARIH2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICARIH2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DARIH2
Mutations and Diseases : HGMDARIH2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ARIH2
DgiDB (Drug Gene Interaction Database)ARIH2
DoCM (Curated mutations)ARIH2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ARIH2 (select a term)
intoGenARIH2
Cancer3DARIH2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605615   
Orphanet
DisGeNETARIH2
MedgenARIH2
Genetic Testing Registry ARIH2
NextProtO95376 [Medical]
TSGene10425
GENETestsARIH2
Target ValidationARIH2
Huge Navigator ARIH2 [HugePedia]
snp3D : Map Gene to Disease10425
BioCentury BCIQARIH2
ClinGenARIH2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10425
Chemical/Pharm GKB GenePA24983
Clinical trialARIH2
Miscellaneous
canSAR (ICR)ARIH2 (select the gene name)
DataMed IndexARIH2
Probes
Litterature
PubMed46 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineARIH2
EVEXARIH2
GoPubMedARIH2
iHOPARIH2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Nov 13 17:32:59 CET 2019
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