ARR3 (arrestin 3)

2008-07-01  

Identity

HGNC
ARR3
LOCATION
Xq13.1
LOCUSID
407
ALIAS
ARRX,MYP26,cArr
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 407
MIM: 301770
HGNC: 710
Ensembl: ENSG00000120500

Variants:

dbSNP: 407
ClinVar: 407
TCGA: ENSG00000120500
COSMIC: ARR3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000120500ENST00000307959P36575
ENSG00000120500ENST00000374495P36575
ENSG00000120500ENST00000480877D6RCT3
ENSG00000120500ENST00000620997A0A087WWQ5

Expression (GTEx)

0
1
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
retina
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
190013752009How does arrestin assemble MAPKs into a signaling complex?68
225230772012Silent scaffolds: inhibition OF c-Jun N-terminal kinase 3 activity in cell by dominant-negative arrestin-3 mutant.48
176809912007Cone arrestin binding to JNK3 and Mdm2: conformational preference and localization of interaction sites.36
188020752008Arrestin 3 mediates endocytosis of CCR7 following ligation of CCL19 but not CCL21.35
128242232003Identification and light-dependent translocation of a cone-specific antigen, cone arrestin, recognized by monoclonal antibody 7G6.23
244127492014Arrestin-3 binds the MAP kinase JNK3α2 via multiple sites on both domains.20
204603842010Internalization of the human nicotinic acid receptor GPR109A is regulated by G(i), GRK2, and arrestin3.17
118774512002Regulation of arrestin-3 phosphorylation by casein kinase II.16
248679532014Identification of receptor binding-induced conformational changes in non-visual arrestins.16
231398252012Distinct cellular and subcellular distributions of G protein-coupled receptor kinase and arrestin isoforms in the striatum.14

Citation

Dessen P

ARR3 (arrestin 3)

Atlas Genet Cytogenet Oncol Haematol. 2008-07-01

Online version: http://atlasgeneticsoncology.org/gene/50226/arr3