ART3 (ADP-ribosyltransferase 3 (inactive))

2018-02-01  

Identity

HGNC
ART3
LOCATION
4q21.1
LOCUSID
419
ALIAS
ARTC3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 419
MIM: 603086
HGNC: 725
Ensembl: ENSG00000156219

Variants:

dbSNP: 419
ClinVar: 419
TCGA: ENSG00000156219
COSMIC: ART3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000156219ENST00000341029Q13508
ENSG00000156219ENST00000349321Q13508
ENSG00000156219ENST00000355810Q13508
ENSG00000156219ENST00000504914E7EX61
ENSG00000156219ENST00000510423E7ER42
ENSG00000156219ENST00000511188Q5J1K9
ENSG00000156219ENST00000513122E7ESB3
ENSG00000156219ENST00000513353E9PGR5

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Post-translational modification: synthesis of GPI-anchored proteinsREACTOMER-HSA-163125

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
182664732008Genome-wide expression of azoospermia testes demonstrates a specific profile and implicates ART3 in genetic susceptibility.33
182664732008Genome-wide expression of azoospermia testes demonstrates a specific profile and implicates ART3 in genetic susceptibility.33
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11
273741772016ART3 regulates triple-negative breast cancer cell function via activation of Akt and ERK pathways.5
166252772006Expression of toxin-related human mono-ADP-ribosyltransferase 3 in human testes.4
169343462006Genomic organization and expression of the human mono-ADP-ribosyltransferase ART3 gene.4

Citation

Dessen P

ART3 (ADP-ribosyltransferase 3 (inactive))

Atlas Genet Cytogenet Oncol Haematol. 2018-02-01

Online version: http://atlasgeneticsoncology.org/gene/57382/art3