ASF1A (anti-silencing function 1A histone chaperone)

2007-02-01 Affiliation

Identity

HGNC

ASF1A

LOCATION

6q22.31

LOCUSID

25842

ALIAS

CGI-98,CIA,HSPC146

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 25842
MIM: 609189
HGNC: 20995
Ensembl: ENSG00000111875

Variants:

dbSNP: 25842
ClinVar: 25842
TCGA: ENSG00000111875
COSMIC: ASF1A

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000111875	ENST00000229595	Q9Y294

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Cellular responses to stress	REACTOME	R-HSA-2262752
Cellular Senescence	REACTOME	R-HSA-2559583
DNA Damage/Telomere Stress Induced Senescence	REACTOME	R-HSA-2559586
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	REACTOME	R-HSA-2559584

References

Pubmed ID	Year	Title	Citations
18096807	2007	Regulation of replication fork progression through histone supply and demand.	196
17293877	2007	Structure and function of the histone chaperone CIA/ASF1 complexed with histones H3 and H4.	137
20227376	2010	Replication stress interferes with histone recycling and predeposition marking of new histones.	117
15664198	2005	Human Asf1 regulates the flow of S phase histones during replicational stress.	115
11897662	2002	Human Asf1 and CAF-1 interact and synergize in a repair-coupled nucleosome assembly pathway.	111
24413054	2014	Rapid induction of alternative lengthening of telomeres by depletion of the histone chaperone ASF1.	101
16980972	2006	Structure of a human ASF1a-HIRA complex and insights into specificity of histone chaperone complex assembly.	76
15840725	2005	Structural basis for the interaction of Asf1 with histone H3 and its functional implications.	67
19029251	2009	Human UBN1 is an ortholog of yeast Hpc2p and has an essential role in the HIRA/ASF1a chromatin-remodeling pathway in senescent cells.	45
25618846	2015	Structural insight into how the human helicase subunit MCM2 may act as a histone chaperone together with ASF1 at the replication fork.	41

Citation

Dessen P

ASF1A (anti-silencing function 1A histone chaperone)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45707/asf1a