ASGR2 (asialoglycoprotein receptor 2)

2021-06-01  

Identity

HGNC
LOCATION
17p13.1
LOCUSID
ALIAS
ASGP-R2,ASGPR2,CLEC4H2,HBXBP,HL-2

Other Information

Locus ID:

NCBI: 433
MIM: 108361
HGNC: 743
Ensembl: ENSG00000161944

Variants:

dbSNP: 433
ClinVar: 433
TCGA: ENSG00000161944
COSMIC: ASGR2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000161944ENST00000254850P07307
ENSG00000161944ENST00000355035P07307
ENSG00000161944ENST00000446679P07307
ENSG00000161944ENST00000574868I3L1H2

Expression (GTEx)

0
50
100
150
200
250
300
350
400

Pathways

PathwaySourceExternal ID
Thyroid hormone synthesisKEGGhsa04918
Thyroid hormone synthesisKEGGko04918
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Asparagine N-linked glycosylationREACTOMER-HSA-446203

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
195208072009Role of sialic acid for platelet life span: exposure of beta-galactose results in the rapid clearance of platelets from the circulation by asialoglycoprotein receptor-expressing liver macrophages and hepatocytes.57
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
271550632016Asialoglycoprotein receptor facilitates infection of PLC/PRF/5 cells by HEV through interaction with ORF2.6
216565382011Hepatocyte cytotoxicity is facilitated by asialoglycoprotein receptor.5
121194732002Expression of a functional asialoglycoprotein receptor in human renal proximal tubular epithelial cells.4
120891592002H2, the minor subunit of the human asialoglycoprotein receptor, trafficks intracellularly and forms homo-oligomers, but does not bind asialo-orosomucoid.2
220965392011A secreted form of the asialoglycoprotein receptor, sH2a, as a novel potential noninvasive marker for liver fibrosis.2
119437872002The minor subunit splice variants, H2b and H2c, of the human asialoglycoprotein receptor are present with the major subunit H1 in different hetero-oligomeric receptor complexes.1
236048022013Expression pattern of asialoglycoprotein receptor in human testis.1
280632652017PEGylation potentiates hepatoma cell targeted liposome-mediated in vitro gene delivery via the asialoglycoprotein receptor.0

Citation

Dessen P

ASGR2 (asialoglycoprotein receptor 2)

Atlas Genet Cytogenet Oncol Haematol. 2021-06-01

Online version: http://atlasgeneticsoncology.org/gene/58199/asgr2