ASIC1 (acid sensing ion channel subunit 1)

2007-05-01  

Identity

HGNC
LOCATION
12q13.12
LOCUSID
ALIAS
ACCN2,ASIC,BNaC2

Other Information

Locus ID:

NCBI: 41
MIM: 602866
HGNC: 100
Ensembl: ENSG00000110881

Variants:

dbSNP: 41
ClinVar: 41
TCGA: ENSG00000110881
COSMIC: ASIC1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000110881ENST00000228468P78348
ENSG00000110881ENST00000447966P78348
ENSG00000110881ENST00000453327H7C1W9
ENSG00000110881ENST00000550558F8VSK4
ENSG00000110881ENST00000552438P78348
ENSG00000110881ENST00000552633H0YHD6

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
Inflammatory mediator regulation of TRP channelsKEGGhsa04750
Inflammatory mediator regulation of TRP channelsKEGGko04750
Transmembrane transport of small moleculesREACTOMER-HSA-382551
Ion channel transportREACTOMER-HSA-983712
Stimuli-sensing channelsREACTOMER-HSA-2672351

References

Pubmed IDYearTitleCitations
383067942024ASIC1 promotes migration and invasion of hepatocellular carcinoma via the PRKACA/AP-1 signaling pathway.0
383067942024ASIC1 promotes migration and invasion of hepatocellular carcinoma via the PRKACA/AP-1 signaling pathway.0
365458822023ASIC1a involves the acid-mediated activation of pancreatic stellate cells associated with autophagy induction.0
365458822023ASIC1a involves the acid-mediated activation of pancreatic stellate cells associated with autophagy induction.0
349183852022Upregulation of acid sensing ion channels is associated with esophageal hypersensitivity in GERD.5
354262242022ASIC1a stimulates the resistance of human hepatocellular carcinoma by promoting EMT via the AKT/GSK3β/Snail pathway driven by TGFβ/Smad signals.8
349183852022Upregulation of acid sensing ion channels is associated with esophageal hypersensitivity in GERD.5
354262242022ASIC1a stimulates the resistance of human hepatocellular carcinoma by promoting EMT via the AKT/GSK3β/Snail pathway driven by TGFβ/Smad signals.8
333927602021Evidence for role of acid-sensing ion channel 1a in chronic rhinosinusitis with nasal polyps.1
335161682021ASIC1 inhibition impairs the proliferation and migration of pancreatic stellate cells induced by pancreatic cancer cells.4
336506622021Acidic microenvironment induction of interleukin-8 expression and matrix metalloproteinase-2/-9 activation via acid-sensing ion channel 1 promotes breast cancer cell progression.4
337291582021Kinetic analysis of ASIC1a delineates conformational signaling from proton-sensing domains to the channel gate.2
338242282021ASIC1 and ASIC3 mediate cellular senescence of human nucleus pulposus mesenchymal stem cells during intervertebral disc degeneration.13
340611612021Mutation of a conserved glutamine residue does not abolish desensitization of acid-sensing ion channel 1.9
341160402021ASIC1a promotes acidic microenvironment-induced HCC cells migration and invasion by inducing autophagy.6

Citation

Dessen P

ASIC1 (acid sensing ion channel subunit 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-05-01

Online version: http://atlasgeneticsoncology.org/gene/47525/asic1