ASIC1 (acid sensing ion channel subunit 1)

2007-05-01  

Identity

HGNC
LOCATION
12q13.12
LOCUSID
ALIAS
ACCN2,ASIC,BNaC2

Other Information

Locus ID:

NCBI: 41
MIM: 602866
HGNC: 100
Ensembl: ENSG00000110881

Variants:

dbSNP: 41
ClinVar: 41
TCGA: ENSG00000110881
COSMIC: ASIC1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000110881ENST00000228468P78348
ENSG00000110881ENST00000447966P78348
ENSG00000110881ENST00000453327H7C1W9
ENSG00000110881ENST00000550558F8VSK4
ENSG00000110881ENST00000552438P78348
ENSG00000110881ENST00000552633H0YHD6

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
Inflammatory mediator regulation of TRP channelsKEGGhsa04750
Inflammatory mediator regulation of TRP channelsKEGGko04750
Transmembrane transport of small moleculesREACTOMER-HSA-382551
Ion channel transportREACTOMER-HSA-983712
Stimuli-sensing channelsREACTOMER-HSA-2672351

References

Pubmed IDYearTitleCitations
123938542002Amiloride-blockable acid-sensing ion channels are leading acid sensors expressed in human nociceptors.96
149885002004Overexpression of acid-sensing ion channel 1a in transgenic mice increases acquired fear-related behavior.77
155747472004Acid-induced pain and its modulation in humans.73
195610782009Knockdown of ASIC1 and epithelial sodium channel subunits inhibits glioblastoma whole cell current and cell migration.48
248470672014Acid-sensing ion channel (ASIC) 1a/2a heteromers have a flexible 2:1/1:2 stoichiometry.33
179840982008Endogenous arginine-phenylalanine-amide-related peptides alter steady-state desensitization of ASIC1a.32
186623362008Regulation of ASIC activity by ASIC4--new insights into ASIC channel function revealed by a yeast two-hybrid assay.29
202994632010A combined computational and functional approach identifies new residues involved in pH-dependent gating of ASIC1a.29
203713172010Demonstration of a direct interaction between sigma-1 receptors and acid-sensing ion channels.29
202165532010Acid-sensing ion channels in acidosis-induced injury of human brain neurons.28

Citation

Dessen P

ASIC1 (acid sensing ion channel subunit 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-05-01

Online version: http://atlasgeneticsoncology.org/gene/47525/asic1