Identity
HGNC
LOCATION
17q11.2
LOCUSID
ALIAS
ACCN,ACCN1,ASIC2a,BNC1,BNaC1,MDEG,hBNaC1
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 40
MIM: 601784
HGNC: 99
Ensembl: ENSG00000108684
Variants:
dbSNP: 40
ClinVar: 40
TCGA: ENSG00000108684
COSMIC: ASIC2
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000108684 | ENST00000225823 | Q16515 |
| ENSG00000108684 | ENST00000359872 | Q16515 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA447199 | Bipolar Disorder | Disease | ClinicalAnnotation | associated | PD | 21961650 | |
| PA450243 | lithium | Chemical | ClinicalAnnotation | associated | PD | 21961650 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 34199609 | 2021 | Expression Profiles of ASIC1/2 and TRPV1/4 in Common Skin Tumors. | 5 |
| 34215968 | 2021 | ASIC2 Synergizes with TRPV1 in the Mechano-Electrical Transduction of Arterial Baroreceptors. | 1 |
| 34199609 | 2021 | Expression Profiles of ASIC1/2 and TRPV1/4 in Common Skin Tumors. | 5 |
| 34215968 | 2021 | ASIC2 Synergizes with TRPV1 in the Mechano-Electrical Transduction of Arterial Baroreceptors. | 1 |
| 30549327 | 2019 | Acid sensing ion channel 2: A new potential player in the pathophysiology of multiple sclerosis. | 11 |
| 31531354 | 2019 | High Expression of Acid-Sensing Ion Channel 2 (ASIC2) in Bone Cells in Osteoporotic Vertebral Fractures. | 5 |
| 30549327 | 2019 | Acid sensing ion channel 2: A new potential player in the pathophysiology of multiple sclerosis. | 11 |
| 31531354 | 2019 | High Expression of Acid-Sensing Ion Channel 2 (ASIC2) in Bone Cells in Osteoporotic Vertebral Fractures. | 5 |
| 28618956 | 2017 | Acid-sensing ion channels contribute to the effect of extracellular acidosis on proliferation and migration of A549 cells. | 30 |
| 28725010 | 2017 | Glucose Deficiency Elevates Acid-Sensing Ion Channel 2a Expression and Increases Seizure Susceptibility in Temporal Lobe Epilepsy. | 9 |
| 28927426 | 2017 | The acid-sensing ion channel, ASIC2, promotes invasion and metastasis of colorectal cancer under acidosis by activating the calcineurin/NFAT1 axis. | 34 |
| 28618956 | 2017 | Acid-sensing ion channels contribute to the effect of extracellular acidosis on proliferation and migration of A549 cells. | 30 |
| 28725010 | 2017 | Glucose Deficiency Elevates Acid-Sensing Ion Channel 2a Expression and Increases Seizure Susceptibility in Temporal Lobe Epilepsy. | 9 |
| 28927426 | 2017 | The acid-sensing ion channel, ASIC2, promotes invasion and metastasis of colorectal cancer under acidosis by activating the calcineurin/NFAT1 axis. | 34 |
| 25744567 | 2016 | Altered Expression Pattern of Acid-Sensing Ion Channel Isoforms in Piriform Cortex After Seizures. | 13 |
Citation
Dessen P
ASIC2 (acid sensing ion channel subunit 2)
Atlas Genet Cytogenet Oncol Haematol. 2003-05-01
Online version: http://atlasgeneticsoncology.org/gene/551/asic2
