ATF7 (activating transcription factor 7)

2008-12-01  

Identity

HGNC
ATF7
LOCATION
12q13.13
LOCUSID
11016
ALIAS
ATFA
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 11016
MIM: 606371
HGNC: 792
Ensembl: ENSG00000170653

Variants:

dbSNP: 11016
ClinVar: 11016
TCGA: ENSG00000170653
COSMIC: ATF7

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000170653ENST00000420353P17544
ENSG00000170653ENST00000456903P17544
ENSG00000170653ENST00000548118P17544
ENSG00000170653ENST00000548446P17544
ENSG00000170653ENST00000551480F8VWG7
ENSG00000170653ENST00000588078K7ESA4
ENSG00000170653ENST00000588232K7EKZ7
ENSG00000170653ENST00000591397P17544

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
267472482016CARMA1- and MyD88-dependent activation of Jun/ATF-type AP-1 complexes is a hallmark of ABC diffuse large B-cell lymphomas.13
297544692018miRNA-103a-3p Promotes Human Gastric Cancer Cell Proliferation by Targeting and Suppressing ATF7 in vitro.11
189506372008p38beta2-mediated phosphorylation and sumoylation of ATF7 are mutually exclusive.8
218580822011A cytoplasmic negative regulator isoform of ATF7 impairs ATF7 and ATF2 phosphorylation and transcriptional activity.7
255453672014Cdk1-mediated phosphorylation of human ATF7 at Thr-51 and Thr-53 promotes cell-cycle progression into M phase.6
234269012013Role of ATF7-TAF12 interactions in the vitamin D response hypersensitivity of osteoclast precursors in Paget's disease.4
286327562017Identification of ATF-7 and the insulin signaling pathway in the regulation of metallothionein in C. elegans suggests roles in aging and reactive oxygen species.4
308918702019Hepatitis B virus-regulated growth of liver cancer cells occurs through the microRNA-340-5p-activating transcription factor 7-heat shock protein A member 1B axis.4
261485932015Expression of activating transcription factor 7 is correlated with prognosis of colorectal cancer.2
261018062015ATF7 is stabilized during mitosis in a CDK1-dependent manner and contributes to cyclin D1 expression.1

Citation

Dessen P

ATF7 (activating transcription factor 7)

Atlas Genet Cytogenet Oncol Haematol. 2008-12-01

Online version: http://atlasgeneticsoncology.org/gene/50476/atf7