ATG12 (autophagy related 12)

2013-09-01  

Identity

HGNC
LOCATION
5q22.3
LOCUSID
ALIAS
APG12,APG12L,FBR93,HAPG12
FUSION GENES

Other Information

Locus ID:

NCBI: 9140
MIM: 609608
HGNC: 588
Ensembl: ENSG00000145782

Variants:

dbSNP: 9140
ClinVar: 9140
TCGA: ENSG00000145782
COSMIC: ATG12

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000145782ENST00000379594H7BYD7
ENSG00000145782ENST00000500945O94817
ENSG00000145782ENST00000505993H0YA29
ENSG00000145782ENST00000509910O94817
ENSG00000145782ENST00000513167H0Y9W4
ENSG00000145782ENST00000513322D6RB14

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
Autophagy - animalKEGGko04140
Autophagy - animalKEGGhsa04140
RIG-I-like receptor signaling pathwayKEGGko04622
RIG-I-like receptor signaling pathwayKEGGhsa04622
NOD-like receptor signaling pathwayKEGGko04621
NOD-like receptor signaling pathwayKEGGhsa04621
FoxO signaling pathwayKEGGhsa04068
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathwaysREACTOMER-HSA-168928
Negative regulators of RIG-I/MDA5 signalingREACTOMER-HSA-936440
Cellular responses to stressREACTOMER-HSA-2262752
MacroautophagyREACTOMER-HSA-1632852
MitophagyREACTOMER-HSA-5205647
Pink/Parkin Mediated MitophagyREACTOMER-HSA-5205685
Autophagy - otherKEGGko04136
Autophagy - otherKEGGhsa04136

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
232025842013Structure of the human ATG12~ATG5 conjugate required for LC3 lipidation in autophagy.109
221524742011The autophagy protein Atg12 associates with antiapoptotic Bcl-2 family members to promote mitochondrial apoptosis.94
191244662009Regulation of autophagy by the p300 acetyltransferase.86
118259102002Human Apg3p/Aut1p homologue is an authentic E2 enzyme for multiple substrates, GATE-16, GABARAP, and MAP-LC3, and facilitates the conjugation of hApg12p to hApg5p.79
199015522010Control of basal autophagy by calpain1 mediated cleavage of ATG5.71
291621582017Long noncoding RNA MALAT1 regulates autophagy associated chemoresistance via miR-23b-3p sequestration in gastric cancer.64
191979482009Frameshift mutations of autophagy-related genes ATG2B, ATG5, ATG9B and ATG12 in gastric and colorectal cancers with microsatellite instability.63
221701532012Autophagy proteins LC3B, ATG5 and ATG12 participate in quality control after mitochondrial damage and influence lifespan.53
233076222012Autophagy-related gene 12 (ATG12) is a novel determinant of primary resistance to HER2-targeted therapies: utility of transcriptome analysis of the autophagy interactome to guide breast cancer treatment.38
247275852014Interaction of caveolin-1 with ATG12-ATG5 system suppresses autophagy in lung epithelial cells.27

Citation

Dessen P

ATG12 (autophagy related 12)

Atlas Genet Cytogenet Oncol Haematol. 2013-09-01

Online version: http://atlasgeneticsoncology.org/gene/53501/atg12