ATOX1 (antioxidant 1 copper chaperone)

2003-06-01  

Identity

HGNC
LOCATION
5q33.1
LOCUSID
ALIAS
ATX1,HAH1
FUSION GENES

Other Information

Locus ID:

NCBI: 475
MIM: 602270
HGNC: 798
Ensembl: ENSG00000177556

Variants:

dbSNP: 475
ClinVar: 475
TCGA: ENSG00000177556
COSMIC: ATOX1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000177556ENST00000313115O00244
ENSG00000177556ENST00000520382E5RGN3
ENSG00000177556ENST00000521264E5RIM7
ENSG00000177556ENST00000522314E5RGN3
ENSG00000177556ENST00000522710O00244
ENSG00000177556ENST00000524142O00244

Expression (GTEx)

0
5
10
15
20
25

Pathways

PathwaySourceExternal ID
Mineral absorptionKEGGko04978
Mineral absorptionKEGGhsa04978
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Cellular responses to stressREACTOMER-HSA-2262752
Detoxification of Reactive Oxygen SpeciesREACTOMER-HSA-3299685
Antimicrobial peptidesREACTOMER-HSA-6803157
Ion influx/efflux at host-pathogen interfaceREACTOMER-HSA-6803544

References

Pubmed IDYearTitleCitations
380416902024Cuproptosis-related gene LIPT1 as a prognostic indicator in non-small cell lung cancer: Functional involvement and regulation of ATOX1 expression.2
380416902024Cuproptosis-related gene LIPT1 as a prognostic indicator in non-small cell lung cancer: Functional involvement and regulation of ATOX1 expression.2
353153402022Copper enhances genotoxic drug resistance via ATOX1 activated DNA damage repair.10
360673182022Memo1 binds reduced copper ions, interacts with copper chaperone Atox1, and protects against copper-mediated redox activity in vitro.0
362080512022Copper coordination states affect the flexibility of copper Metallochaperone Atox1: Insights from molecular dynamics simulations.0
362917032022Crystal Structure of the Human Copper Chaperone ATOX1 Bound to Zinc Ion.2
353153402022Copper enhances genotoxic drug resistance via ATOX1 activated DNA damage repair.10
360673182022Memo1 binds reduced copper ions, interacts with copper chaperone Atox1, and protects against copper-mediated redox activity in vitro.0
362080512022Copper coordination states affect the flexibility of copper Metallochaperone Atox1: Insights from molecular dynamics simulations.0
362917032022Crystal Structure of the Human Copper Chaperone ATOX1 Bound to Zinc Ion.2
345506322021APEX2-based Proximity Labeling of Atox1 Identifies CRIP2 as a Nuclear Copper-binding Protein that Regulates Autophagy Activation.13
345506322021APEX2-based Proximity Labeling of Atox1 Identifies CRIP2 as a Nuclear Copper-binding Protein that Regulates Autophagy Activation.13
318981572020Evaluation of copper chaperone ATOX1 as prognostic biomarker in breast cancer.14
319324352020Single-cell tracking demonstrates copper chaperone Atox1 to be required for breast cancer cell migration.0
319618922020Nuclear translocation of Atox1 potentiates activin A-induced cell migration and colony formation in colon cancer.18

Citation

Dessen P

ATOX1 (antioxidant 1 copper chaperone)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/720/atox1