Identity
HGNC
LOCATION
Xq27.1
LOCUSID
ALIAS
ATPIG,ATPIQ,HACXL
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 286410
MIM: 300516
HGNC: 13554
Ensembl: ENSG00000101974
Variants:
dbSNP: 286410
ClinVar: 286410
TCGA: ENSG00000101974
COSMIC: ATP11C
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Transmembrane transport of small molecules | REACTOME | R-HSA-382551 |
| Ion channel transport | REACTOME | R-HSA-983712 |
| Ion transport by P-type ATPases | REACTOME | R-HSA-936837 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36753036 | 2023 | ATP11C promotes the differentiation of pre-B cells into immature B cells but does not affect their IL-7-dependent proliferation. | 0 |
| 37671681 | 2023 | A novel missense variant in ATP11C is associated with reduced red blood cell phosphatidylserine flippase activity and mild hereditary hemolytic anemia. | 2 |
| 36753036 | 2023 | ATP11C promotes the differentiation of pre-B cells into immature B cells but does not affect their IL-7-dependent proliferation. | 0 |
| 37671681 | 2023 | A novel missense variant in ATP11C is associated with reduced red blood cell phosphatidylserine flippase activity and mild hereditary hemolytic anemia. | 2 |
| 34651249 | 2022 | The ratio of ATP11C/PLSCR1 mRNA transcripts has clinical significance in sickle cell anemia. | 1 |
| 36162506 | 2022 | Two types of type IV P-type ATPases independently re-establish the asymmetrical distribution of phosphatidylserine in plasma membranes. | 2 |
| 34651249 | 2022 | The ratio of ATP11C/PLSCR1 mRNA transcripts has clinical significance in sickle cell anemia. | 1 |
| 36162506 | 2022 | Two types of type IV P-type ATPases independently re-establish the asymmetrical distribution of phosphatidylserine in plasma membranes. | 2 |
| 32493773 | 2020 | Crystal structure of a human plasma membrane phospholipid flippase. | 27 |
| 32997992 | 2020 | Transport Cycle of Plasma Membrane Flippase ATP11C by Cryo-EM. | 30 |
| 33103382 | 2020 | Reduction in flippase activity contributes to surface presentation of phosphatidylserine in human senescent erythrocytes. | 7 |
| 32493773 | 2020 | Crystal structure of a human plasma membrane phospholipid flippase. | 27 |
| 32997992 | 2020 | Transport Cycle of Plasma Membrane Flippase ATP11C by Cryo-EM. | 30 |
| 33103382 | 2020 | Reduction in flippase activity contributes to surface presentation of phosphatidylserine in human senescent erythrocytes. | 7 |
| 31253392 | 2019 | ATP11C T418N, a gene mutation causing congenital hemolytic anemia, reduces flippase activity due to improper membrane trafficking. | 3 |
Citation
Dessen P
ATP11C (ATPase phospholipid transporting 11C)
Atlas Genet Cytogenet Oncol Haematol. 2011-10-01
Online version: http://atlasgeneticsoncology.org/gene/52394/atp11c
