ATP1A3 (ATPase Na+/K+ transporting subunit alpha 3)

2011-05-01  

Identity

HGNC
LOCATION
19q13.2
LOCUSID
ALIAS
AHC2,ATP1A1,CAPOS,DYT12,RDP
FUSION GENES

Other Information

Locus ID:

NCBI: 478
MIM: 182350
HGNC: 801
Ensembl: ENSG00000105409

Variants:

dbSNP: 478
ClinVar: 478
TCGA: ENSG00000105409
COSMIC: ATP1A3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000105409ENST00000441343A0A0A0MT26
ENSG00000105409ENST00000473086M0QXF2
ENSG00000105409ENST00000543770P13637
ENSG00000105409ENST00000545399P13637
ENSG00000105409ENST00000602133M0R116
ENSG00000105409ENST00000648268P13637

Expression (GTEx)

0
50
100
150
200
250
300
350
400

Pathways

PathwaySourceExternal ID
Cardiac muscle contractionKEGGhsa04260
Cardiac muscle contractionKEGGko04260
Aldosterone-regulated sodium reabsorptionKEGGko04960
Aldosterone-regulated sodium reabsorptionKEGGhsa04960
Proximal tubule bicarbonate reclamationKEGGko04964
Proximal tubule bicarbonate reclamationKEGGhsa04964
Salivary secretionKEGGko04970
Salivary secretionKEGGhsa04970
Gastric acid secretionKEGGko04971
Gastric acid secretionKEGGhsa04971
Pancreatic secretionKEGGko04972
Pancreatic secretionKEGGhsa04972
Carbohydrate digestion and absorptionKEGGko04973
Carbohydrate digestion and absorptionKEGGhsa04973
Protein digestion and absorptionKEGGko04974
Protein digestion and absorptionKEGGhsa04974
Bile secretionKEGGko04976
Bile secretionKEGGhsa04976
Mineral absorptionKEGGko04978
Mineral absorptionKEGGhsa04978
Endocrine and other factor-regulated calcium reabsorptionKEGGko04961
Endocrine and other factor-regulated calcium reabsorptionKEGGhsa04961
Insulin secretionKEGGhsa04911
Thyroid hormone synthesisKEGGhsa04918
Thyroid hormone synthesisKEGGko04918
Adrenergic signaling in cardiomyocytesKEGGhsa04261
Adrenergic signaling in cardiomyocytesKEGGko04261
Thyroid hormone signaling pathwayKEGGhsa04919
cGMP-PKG signaling pathwayKEGGhsa04022
cGMP-PKG signaling pathwayKEGGko04022
cAMP signaling pathwayKEGGhsa04024
cAMP signaling pathwayKEGGko04024
Muscle contractionREACTOMER-HSA-397014
Transmembrane transport of small moleculesREACTOMER-HSA-382551
Ion channel transportREACTOMER-HSA-983712
Ion transport by P-type ATPasesREACTOMER-HSA-936837
Cardiac conductionREACTOMER-HSA-5576891
Ion homeostasisREACTOMER-HSA-5578775

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
382430452024Childhood-related neural genotype-phenotype in ATP1A3 mutations: comprehensive analysis.1
387964842024Neuronal autosis is Na(+)/K(+)-ATPase alpha 3-dependent and involved in hypoxic-ischemic neuronal death.0
382430452024Childhood-related neural genotype-phenotype in ATP1A3 mutations: comprehensive analysis.1
387964842024Neuronal autosis is Na(+)/K(+)-ATPase alpha 3-dependent and involved in hypoxic-ischemic neuronal death.0
364626652023Temperature instability of a mutation at a multidomain junction in Na,K-ATPase isoform ATP1A3 (p.Arg756His) produces a fever-induced neurological syndrome.3
364848642023ATP1A3-related phenotypes in Chinese children: AHC, CAPOS, and RECA.1
365381312023Germline mosaicism for a disease-causing mutation in the ATP1A3 gene in a Chinese family.0
374823772023Expanding the Allelic spectrum in ATP1A3-related disorders with 3 novel mutations and clinic features.0
377134942023ATP1A3 as a target for isolating neuron-specific extracellular vesicles from human brain and biofluids.8
364626652023Temperature instability of a mutation at a multidomain junction in Na,K-ATPase isoform ATP1A3 (p.Arg756His) produces a fever-induced neurological syndrome.3
364848642023ATP1A3-related phenotypes in Chinese children: AHC, CAPOS, and RECA.1
365381312023Germline mosaicism for a disease-causing mutation in the ATP1A3 gene in a Chinese family.0
374823772023Expanding the Allelic spectrum in ATP1A3-related disorders with 3 novel mutations and clinic features.0
377134942023ATP1A3 as a target for isolating neuron-specific extracellular vesicles from human brain and biofluids.8
346331432022Vanishing basal ganglia in ATP1A3-related polymicrogyria.0

Citation

Dessen P

ATP1A3 (ATPase Na+/K+ transporting subunit alpha 3)

Atlas Genet Cytogenet Oncol Haematol. 2011-05-01

Online version: http://atlasgeneticsoncology.org/gene/52224/atp1a3