ATP1A4 (ATPase Na+/K+ transporting subunit alpha 4)

2014-11-01  

Identity

HGNC
LOCATION
1q23.2
LOCUSID
ALIAS
ATP1A1,ATP1AL2
FUSION GENES

Other Information

Locus ID:

NCBI: 480
MIM: 607321
HGNC: 14073
Ensembl: ENSG00000132681

Variants:

dbSNP: 480
ClinVar: 480
TCGA: ENSG00000132681
COSMIC: ATP1A4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000132681ENST00000368081Q13733
ENSG00000132681ENST00000470705Q13733
ENSG00000132681ENST00000477338E9PRA5

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
Cardiac muscle contractionKEGGhsa04260
Cardiac muscle contractionKEGGko04260
Aldosterone-regulated sodium reabsorptionKEGGko04960
Aldosterone-regulated sodium reabsorptionKEGGhsa04960
Proximal tubule bicarbonate reclamationKEGGko04964
Proximal tubule bicarbonate reclamationKEGGhsa04964
Salivary secretionKEGGko04970
Salivary secretionKEGGhsa04970
Gastric acid secretionKEGGko04971
Gastric acid secretionKEGGhsa04971
Pancreatic secretionKEGGko04972
Pancreatic secretionKEGGhsa04972
Carbohydrate digestion and absorptionKEGGko04973
Carbohydrate digestion and absorptionKEGGhsa04973
Protein digestion and absorptionKEGGko04974
Protein digestion and absorptionKEGGhsa04974
Bile secretionKEGGko04976
Bile secretionKEGGhsa04976
Mineral absorptionKEGGko04978
Mineral absorptionKEGGhsa04978
Endocrine and other factor-regulated calcium reabsorptionKEGGko04961
Endocrine and other factor-regulated calcium reabsorptionKEGGhsa04961
Insulin secretionKEGGhsa04911
Thyroid hormone synthesisKEGGhsa04918
Thyroid hormone synthesisKEGGko04918
Adrenergic signaling in cardiomyocytesKEGGhsa04261
Adrenergic signaling in cardiomyocytesKEGGko04261
Thyroid hormone signaling pathwayKEGGhsa04919
cGMP-PKG signaling pathwayKEGGhsa04022
cGMP-PKG signaling pathwayKEGGko04022
cAMP signaling pathwayKEGGhsa04024
cAMP signaling pathwayKEGGko04024
Muscle contractionREACTOMER-HSA-397014
Transmembrane transport of small moleculesREACTOMER-HSA-382551
Ion channel transportREACTOMER-HSA-983712
Ion transport by P-type ATPasesREACTOMER-HSA-936837
Cardiac conductionREACTOMER-HSA-5576891
Ion homeostasisREACTOMER-HSA-5578775

References

Pubmed IDYearTitleCitations
161756382006The human Na,K-ATPase alpha 4 isoform is a ouabain-sensitive alpha isoform that is expressed in sperm.14
168945552006The transcription factor CREMtau and cAMP regulate promoter activity of the Na,K-ATPase alpha4 isoform.8
256402462015Role of human Na,K-ATPase alpha 4 in sperm function, derived from studies in transgenic mice.4

Citation

Dessen P

ATP1A4 (ATPase Na+/K+ transporting subunit alpha 4)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/60617/atp1a4