Identity
HGNC
LOCATION
12q24.11
LOCUSID
ALIAS
ATP2B,DAR,DD,SERCA2
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 488
MIM: 108740
HGNC: 812
Ensembl: ENSG00000174437
Variants:
dbSNP: 488
ClinVar: 488
TCGA: ENSG00000174437
COSMIC: ATP2A2
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA448871 | celecoxib | Chemical | Pathway | associated | 22336956 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38339835 | 2024 | IL-37 Modulates Myocardial Calcium Handling via the p-STAT3/SERCA2a Axis in HF-Related Engineered Human Heart Tissue. | 0 |
| 38339835 | 2024 | IL-37 Modulates Myocardial Calcium Handling via the p-STAT3/SERCA2a Axis in HF-Related Engineered Human Heart Tissue. | 0 |
| 36834924 | 2023 | Identification and Characterization of p300-Mediated Lysine Residues in Cardiac SERCA2a. | 1 |
| 36876489 | 2023 | Disruption of Phosphodiesterase 3A Binding to SERCA2 Increases SERCA2 Activity and Reduces Mortality in Mice With Chronic Heart Failure. | 4 |
| 37132526 | 2023 | Familial comedonal Darier's disease: a new ATP2A2 mutation with intra-family clinical heterogeneity. | 0 |
| 37195706 | 2023 | Association of Somatic ATP2A2 Damaging Variants With Grover Disease. | 5 |
| 37291092 | 2023 | SERCA2 phosphorylation at serine 663 is a key regulator of Ca(2+) homeostasis in heart diseases. | 0 |
| 37572431 | 2023 | SERCA2 phosphorylation at the heart of the disease. | 1 |
| 37738362 | 2023 | Mitochondria-ER contact mediated by MFN2-SERCA2 interaction supports CD8(+) T cell metabolic fitness and function in tumors. | 4 |
| 36834924 | 2023 | Identification and Characterization of p300-Mediated Lysine Residues in Cardiac SERCA2a. | 1 |
| 36876489 | 2023 | Disruption of Phosphodiesterase 3A Binding to SERCA2 Increases SERCA2 Activity and Reduces Mortality in Mice With Chronic Heart Failure. | 4 |
| 37132526 | 2023 | Familial comedonal Darier's disease: a new ATP2A2 mutation with intra-family clinical heterogeneity. | 0 |
| 37195706 | 2023 | Association of Somatic ATP2A2 Damaging Variants With Grover Disease. | 5 |
| 37291092 | 2023 | SERCA2 phosphorylation at serine 663 is a key regulator of Ca(2+) homeostasis in heart diseases. | 0 |
| 37572431 | 2023 | SERCA2 phosphorylation at the heart of the disease. | 1 |
Citation
Dessen P
ATP2A2 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2)
Atlas Genet Cytogenet Oncol Haematol. 2003-06-01
Online version: http://atlasgeneticsoncology.org/gene/723/atp2a2
