ATP2A2 (ATPase, Ca++ transporting, cardiac muscle, slow twitch 2)

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Taking over the Atlas
Dear Colleagues,
The Atlas, once more, is in great danger, and I will have to proceed to a collective economic lay-off of all the team involved in the Atlas before the begining of April 2015 (a foundation having suddenly withdrawn its commitment to support the Atlas). I ask you herein if any Scientific Society (a Society of Cytogenetics, of Clinical Genetics, of Hematology, or a Cancer Society, or any other...), any University and/or Hospital, any Charity, or any database would be interested in taking over the Atlas, in whole or in part. If taking charge of the whole lot is too big, a consortium of various actors could be the solution (I am myself trying to find partners). Could you please spread the information, contact the relevant authorities, and find partners.
Survival of the Atlas will be critically dependant upon your ability to find solutions (and urgently!).
Kind regards.
Jean-Loup Huret
Donations are also welcome

ATP2A2 (ATPase, Ca++ transporting, cardiac muscle, slow twitch 2)

Identity

Other names	ATP2B
	DAR
	DD
	SERCA2
HGNC (Hugo)	ATP2A2
LocusID (NCBI)	488
Location	12q24.11
Location_base_pair	Starts at 110719032 and ends at 110788897 bp from pter ( according to hg19-Feb_2009)
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to How to contribute

DNA/RNA

External links

	Nomenclature
HGNC (Hugo)	ATP2A2 812
	Cards
Entrez_Gene (NCBI)	ATP2A2 488 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
GeneCards (Weizmann)	ATP2A2
Ensembl hg19 (Hinxton)	ENSG00000174437 [Gene_View] chr12:110719032-110788897 [Contig_View] ATP2A2 [Vega]
Ensembl hg38 (Hinxton)	ENSG00000174437 [Gene_View] chr12:110719032-110788897 [Contig_View] ATP2A2 [Vega]
ICGC DataPortal	ENSG00000174437
cBioPortal	ATP2A2
AceView (NCBI)	ATP2A2
Genatlas (Paris)	ATP2A2
WikiGenes	488
SOURCE (Princeton)	ATP2A2
	Genomic and cartography
GoldenPath hg19 (UCSC)	ATP2A2 - chr12:110719032-110788897 + 12q24.11 [Description] (hg19-Feb_2009)
GoldenPath hg38 (UCSC)	ATP2A2 - 12q24.11 [Description] (hg38-Dec_2013)
Ensembl	ATP2A2 - 12q24.11 [CytoView hg19] ATP2A2 - 12q24.11 [CytoView hg38]
Mapping of homologs : NCBI	ATP2A2 [Mapview hg19] ATP2A2 [Mapview hg38]
OMIM	101900 108740 124200
	Gene and transcription
Genbank (Entrez)	AK000300 AK095382 AK293877 AL117505 AY186578
RefSeq transcript (Entrez)	NM_001135765 NM_001681 NM_170665
RefSeq genomic (Entrez)	AC_000144 NC_000012 NC_018923 NG_007097 NT_029419 NW_001838062 NW_004929385
Consensus coding sequences : CCDS (NCBI)	ATP2A2
Cluster EST : Unigene	Hs.506759 [ NCBI ]
CGAP (NCI)	Hs.506759
Alternative Splicing : Fast-db (Paris)	GSHG0006998
Alternative Splicing Gallery	ENSG00000174437
Gene Expression	ATP2A2 [ NCBI-GEO ] ATP2A2 [ SEEK ] ATP2A2 [ MEM ]
SOURCE (Princeton)	Expression in : [Normal Tissue Atlas] [carcinoma Classsification] [NCI60]
	Protein : pattern, domain, 3D structure
UniProt/SwissProt	P16615 (Uniprot)
NextProt	P16615 [Medical]
With graphics : InterPro	P16615
Splice isoforms : SwissVar	P16615 (Swissvar)
Catalytic activity : Enzyme	3.6.3.8 [ Enzyme-Expasy ] 3.6.3.8 3.6.3.8 [ IntEnz-EBI ] 3.6.3.8 [ BRENDA ] 3.6.3.8 [ KEGG ]
Domaine pattern : Prosite (Expaxy)	ATPASE_E1_E2 (PS00154)
Domains : Interpro (EBI)	ATPase_P-typ_Ca-transp_IIA ATPase_P-typ_cation-transptr_C ATPase_P-typ_cation-transptr_N ATPase_P-typ_cyto_domN ATPase_P-typ_P_site ATPase_P-typ_TM_dom ATPase_P-typ_transduc_dom_A Cation_transp_P_typ_ATPase HAD-like_dom
Related proteins : CluSTr	P16615
Domain families : Pfam (Sanger)	Cation_ATPase_C (PF00689) Cation_ATPase_N (PF00690) E1-E2_ATPase (PF00122) Hydrolase (PF00702)
Domain families : Pfam (NCBI)	pfam00689 pfam00690 pfam00122 pfam00702
Domain families : Smart (EMBL)	Cation_ATPase_N (SM00831)
DMDM Disease mutations	488
Blocks (Seattle)	P16615
Human Protein Atlas	ENSG00000174437
Peptide Atlas	P16615
HPRD	00161
IPI	IPI00219078 IPI00177817 IPI00969023 IPI00914019 IPI00747443 IPI01022616 IPI01021755 IPI01022258 IPI01026572 IPI01022709
	Protein Interaction databases
DIP (DOE-UCLA)	P16615
IntAct (EBI)	P16615
FunCoup	ENSG00000174437
BioGRID	ATP2A2
IntegromeDB	ATP2A2
STRING (EMBL)	ATP2A2
	Ontologies - Pathways
QuickGO	P16615
Ontology : AmiGO	regulation of the force of heart contraction calcium-transporting ATPase activity protein binding ATP binding endoplasmic reticulum membrane endoplasmic reticulum membrane integral component of plasma membrane transport cellular calcium ion homeostasis ER-nucleus signaling pathway cell adhesion blood coagulation protein C-terminus binding metabolic process epidermis development positive regulation of heart rate membrane sarcoplasmic reticulum enzyme binding platelet dense tubular network membrane sarcoplasmic reticulum membrane ion transmembrane transport intracellular membrane-bounded organelle S100 protein binding negative regulation of heart contraction metal ion binding transmembrane transport relaxation of cardiac muscle sarcoplasmic reticulum calcium ion transport calcium ion transmembrane transport calcium ion transmembrane transport regulation of cardiac muscle cell membrane potential calcium-transporting ATPase activity involved in regulation of cardiac muscle cell membrane potential
Ontology : EGO-EBI	regulation of the force of heart contraction calcium-transporting ATPase activity protein binding ATP binding endoplasmic reticulum membrane endoplasmic reticulum membrane integral component of plasma membrane transport cellular calcium ion homeostasis ER-nucleus signaling pathway cell adhesion blood coagulation protein C-terminus binding metabolic process epidermis development positive regulation of heart rate membrane sarcoplasmic reticulum enzyme binding platelet dense tubular network membrane sarcoplasmic reticulum membrane ion transmembrane transport intracellular membrane-bounded organelle S100 protein binding negative regulation of heart contraction metal ion binding transmembrane transport relaxation of cardiac muscle sarcoplasmic reticulum calcium ion transport calcium ion transmembrane transport calcium ion transmembrane transport regulation of cardiac muscle cell membrane potential calcium-transporting ATPase activity involved in regulation of cardiac muscle cell membrane potential
Pathways : KEGG	Calcium signaling pathway Cardiac muscle contraction Adrenergic signaling in cardiomyocytes Thyroid hormone signaling pathway Pancreatic secretion Alzheimer's disease Hypertrophic cardiomyopathy (HCM) Arrhythmogenic right ventricular cardiomyopathy (ARVC) Dilated cardiomyopathy
Protein Interaction Database	ATP2A2
DoCM (Curated mutations)	ATP2A2
Wikipedia pathways	ATP2A2
	Gene fusion - rearrangements
	Polymorphisms : SNP, variants
NCBI Variation Viewer	ATP2A2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)	ATP2A2
dbVar	ATP2A2
ClinVar	ATP2A2
1000_Genomes	ATP2A2
Exome Variant Server	ATP2A2
SNP (GeneSNP Utah)	ATP2A2
SNP : HGBase	ATP2A2
Genetic variants : HAPMAP	ATP2A2
Genomic Variants (DGV)	ATP2A2 [DGVbeta]
	Mutations
ICGC Data Portal	ENSG00000174437
Somatic Mutations in Cancer : COSMIC	ATP2A2
CONAN: Copy Number Analysis	ATP2A2
LOVD (Leiden Open Variation Database)	Whole genome datasets
LOVD (Leiden Open Variation Database)	LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)	Mendelian genes
Impact of mutations	[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor]
	Diseases
DECIPHER (Syndromes)	12:110719032-110788897
Mutations and Diseases : HGMD	ATP2A2
OMIM	101900 108740 124200
Medgen	ATP2A2
NextProt	P16615 [Medical]
GENETests	ATP2A2
Disease Genetic Association	ATP2A2
Huge Navigator	ATP2A2 [HugePedia] ATP2A2 [HugeCancerGEM]
snp3D : Map Gene to Disease	488
DGIdb (Drug Gene Interaction db)	ATP2A2
	General knowledge
Homologs : HomoloGene	ATP2A2
Homology/Alignments : Family Browser (UCSC)	ATP2A2
Phylogenetic Trees/Animal Genes : TreeFam	ATP2A2
Chemical/Protein Interactions : CTD	488
Chemical/Pharm GKB Gene	PA71
Clinical trial	ATP2A2
Cancer Resource (Charite)	ENSG00000174437
	Other databases
	Probes
	Litterature
PubMed	171 Pubmed reference(s) in Entrez
CoreMine	ATP2A2
GoPubMed	ATP2A2
iHOP	ATP2A2

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S

Updated	12-2014	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Sat Feb 14 14:45:30 CET 2015

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