ATP4B (ATPase H+/K+ transporting subunit beta)

2013-07-01  

Identity

HGNC
LOCATION
13q34
LOCUSID
ALIAS
ATP6B

Other Information

Locus ID:

NCBI: 496
MIM: 137217
HGNC: 820
Ensembl: ENSG00000186009

Variants:

dbSNP: 496
ClinVar: 496
TCGA: ENSG00000186009
COSMIC: ATP4B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000186009ENST00000335288P51164

Expression (GTEx)

0
500
1000
1500

Pathways

PathwaySourceExternal ID
Oxidative phosphorylationKEGGko00190
Oxidative phosphorylationKEGGhsa00190
Collecting duct acid secretionKEGGko04966
Collecting duct acid secretionKEGGhsa04966
Gastric acid secretionKEGGko04971
Gastric acid secretionKEGGhsa04971
Transmembrane transport of small moleculesREACTOMER-HSA-382551
Ion channel transportREACTOMER-HSA-983712
Ion transport by P-type ATPasesREACTOMER-HSA-936837

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
151557142004Prolonged exercise to fatigue in humans impairs skeletal muscle Na+-K+-ATPase activity, sarcoplasmic reticulum Ca2+ release, and Ca2+ uptake.19
118659752001BCL-2 is involved in preventing oxidant-induced cell death and in decreasing oxygen radical production.10
196944092009A C-terminal lobe of the beta subunit of Na,K-ATPase and H,K-ATPase resembles cell adhesion molecules.8
233172182012Intragenic DNA methylation concomitant with repression of ATP4B and ATP4A gene expression in gastric cancer is a potential serum biomarker.6
187875072008Pharmacological effects of lipid-lowering drugs recapitulate with a larger amplitude the phenotypic effects of common variants within their target genes.3
247001952014Benzimidazole derivative, BMT-1, induces apoptosis in multiple myeloma cells via a mitochondrial-mediated pathway involving H+/K+-ATPase inhibition.3
146858602004Effect of resistance training on Na,K pump and Na+/H+ exchange protein densities in muscle from control and patients with type 2 diabetes.1

Citation

Dessen P

ATP4B (ATPase H+/K+ transporting subunit beta)

Atlas Genet Cytogenet Oncol Haematol. 2013-07-01

Online version: http://atlasgeneticsoncology.org/gene/53468/atp4b