ATP6V0D2 (ATPase H+ transporting V0 subunit d2)

2016-10-01  

Identity

HGNC
LOCATION
8q21.3
LOCUSID
ALIAS
ATP6D2,VMA6

Other Information

Locus ID:

NCBI: 245972
MIM: 618072
HGNC: 18266
Ensembl: ENSG00000147614

Variants:

dbSNP: 245972
ClinVar: 245972
TCGA: ENSG00000147614
COSMIC: ATP6V0D2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000147614ENST00000285393Q8N8Y2
ENSG00000147614ENST00000285393A0A024R991
ENSG00000147614ENST00000521564E5RHJ7
ENSG00000147614ENST00000523635E5RIR3

Expression (GTEx)

0
5
10
15
20
25
30
35

Pathways

PathwaySourceExternal ID
Oxidative phosphorylationKEGGko00190
Vibrio cholerae infectionKEGGko05110
Epithelial cell signaling in Helicobacter pylori infectionKEGGko05120
Oxidative phosphorylationKEGGhsa00190
Vibrio cholerae infectionKEGGhsa05110
Epithelial cell signaling in Helicobacter pylori infectionKEGGhsa05120
LysosomeKEGGko04142
LysosomeKEGGhsa04142
Metabolic pathwaysKEGGhsa01100
Collecting duct acid secretionKEGGko04966
Collecting duct acid secretionKEGGhsa04966
PhagosomeKEGGko04145
PhagosomeKEGGhsa04145
Rheumatoid arthritisKEGGko05323
Rheumatoid arthritisKEGGhsa05323
TuberculosisKEGGko05152
TuberculosisKEGGhsa05152
Synaptic vesicle cycleKEGGko04721
Synaptic vesicle cycleKEGGhsa04721
V-type ATPase, eukaryotesKEGGhsa_M00160
V-type ATPase, eukaryotesKEGGM00160
Viral carcinogenesisKEGGhsa05203
Viral carcinogenesisKEGGko05203
ROS, RNS production in phagocytesREACTOMER-HSA-1222556
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Signal TransductionREACTOMER-HSA-162582
Signaling by Insulin receptorREACTOMER-HSA-74752
Insulin receptor recyclingREACTOMER-HSA-77387
Transmembrane transport of small moleculesREACTOMER-HSA-382551
Iron uptake and transportREACTOMER-HSA-917937
Transferrin endocytosis and recyclingREACTOMER-HSA-917977
Ion channel transportREACTOMER-HSA-983712

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
304314392019Lactate inhibits ATP6V0d2 expression in tumor-associated macrophages to promote HIF-2α-mediated tumor progression.8
198187312009Adrm1 interacts with Atp6v0d2 and regulates osteoclast differentiation.5
300668392018Vγ9Vδ2 T cells inhibit immature dendritic cell transdifferentiation into osteoclasts through downregulation of RANK, c‑Fos and ATP6V0D2.2
246319252014Expression, purification and characterization of human vacuolar-type H(+)-ATPase subunit d1 and d2 in Escherichia coli.0

Citation

Dessen P

ATP6V0D2 (ATPase H+ transporting V0 subunit d2)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56085/atp6v0d2