ATP7B (ATPase, Cu++ transporting, beta polypeptide)

Identity

Other names	PWD
	WC1
	WD
	WND
HGNC	ATP7B
Location	13q14.3
Location_base_pair	Starts at 51404806 and ends at 51483631 bp from pter ( according to hg18-March_2006).
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	ATP7B   870
Entrez_Gene	ATP7B  540  ATPase, Cu++ transporting, beta polypeptide
	Cards
GeneCards	ATP7B
Ensembl	ATP7B [Search_View]   ENSG00000123191 [Gene_View]
Genatlas	ATP7B
GeneLynx	ATP7B
eGenome	ATP7B
euGene	540
	Genomic and cartography
GoldenPath	ATP7B  -  13q14.3   chr13:51404806-51483631 -  13q14.3   [Description]    (hg18-March_2006)
Ensembl	ATP7B - 13q14.3 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	ATP7B
	Gene and transcription
Genbank	AA047378 [ ENTREZ ]
Genbank	AB209461 [ ENTREZ ]
Genbank	BC117200 [ ENTREZ ]
Genbank	BX479483 [ ENTREZ ]
Genbank	BX648261 [ ENTREZ ]
RefSeq	NM_000053 [ SRS ]    NM_000053 [ ENTREZ ]
RefSeq	NM_001005918 [ SRS ]    NM_001005918 [ ENTREZ ]
RefSeq	AC_000056 [ SRS ]    AC_000056 [ ENTREZ ]
RefSeq	AC_000145 [ SRS ]    AC_000145 [ ENTREZ ]
RefSeq	NC_000013 [ SRS ]    NC_000013 [ ENTREZ ]
RefSeq	NT_024524 [ SRS ]    NT_024524 [ ENTREZ ]
RefSeq	NW_001838074 [ SRS ]    NW_001838074 [ ENTREZ ]
RefSeq	NW_925473 [ SRS ]    NW_925473 [ ENTREZ ]
AceView	ATP7B AceView - NCBI
Unigene	Hs.492280 [ SRS ]    Hs.492280 [ NCBI ]     HS492280 [ spliceNest ]
Fast-db	5793 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	P35670 [ SRS]    P35670 [ EXPASY ]     P35670 [ INTERPRO ]     P35670 [ UNIPROT ]
Prosite	PS00154 ATPASE_E1_E2 [ SRS ]    PS00154 ATPASE_E1_E2 [ Expasy ]
Prosite	PS01047 HMA_1 [ SRS ]    PS01047 HMA_1 [ Expasy ]
Prosite	PS50846 HMA_2 [ SRS ]    PS50846 HMA_2 [ Expasy ]
Interpro	IPR006416 ATPase-IB_hvy [ SRS ]    IPR006416 ATPase-IB_hvy [ EBI ]
Interpro	IPR001757 ATPase_P [ SRS ]    IPR001757 ATPase_P [ EBI ]
Interpro	IPR006403 ATPase_P_cat/Cu [ SRS ]    IPR006403 ATPase_P_cat/Cu [ EBI ]
Interpro	IPR001877 Cu_ATPase1 [ SRS ]    IPR001877 Cu_ATPase1 [ EBI ]
Interpro	IPR006122 Cu_ion_bd [ SRS ]    IPR006122 Cu_ion_bd [ EBI ]
Interpro	IPR005834 Dehalogen-like_hydro [ SRS ]    IPR005834 Dehalogen-like_hydro [ EBI ]
Interpro	IPR008250 E1-E2_ATPase_reg [ SRS ]    IPR008250 E1-E2_ATPase_reg [ EBI ]
Interpro	IPR006121 HeavyMe_transpt [ SRS ]    IPR006121 HeavyMe_transpt [ EBI ]
CluSTr	P35670
Pfam	PF00122 E1-E2_ATPase [ SRS ]    PF00122 E1-E2_ATPase [ Sanger ]    pfam00122 [ NCBI-CDD ]
Pfam	PF00403 HMA [ SRS ]    PF00403 HMA [ Sanger ]    pfam00403 [ NCBI-CDD ]
Pfam	PF00702 Hydrolase [ SRS ]    PF00702 Hydrolase [ Sanger ]    pfam00702 [ NCBI-CDD ]
Blocks	P35670
PDB	2ARF [ SRS ]    2ARF [ PdbSum ],   2ARF [ IMB ]   2ARF [ RSDB ]
PDB	2EW9 [ SRS ]    2EW9 [ PdbSum ],   2EW9 [ IMB ]   2EW9 [ RSDB ]
HPRD	06050
	Protein Interaction databases
DIP	P35670
IntAct	P35670
	Polymorphism : SNP, mutations, diseases
OMIM	277900;606882    [ map ]
GENECLINICS	277900;606882
SNP	ATP7B [dbSNP-NCBI]
SNP	NM_000053 [SNP-NCI]
SNP	NM_001005918 [SNP-NCI]
SNP	ATP7B [GeneSNPs - Utah]  ATP7B] [HGBASE - SRS]
HAPMAP	ATP7B [HAPMAP]
HGMD	ATP7B
	General knowledge
Family Browser	ATP7B [UCSC Family Browser]
SOURCE	NM_000053
SOURCE	NM_001005918
SMD	Hs.492280
SAGE	Hs.492280
Enzyme	3.6.3.4 [ Enzyme-Expasy ]   3.6.3.4 [ Enzyme-SRS ]   3.6.3.4 [ IntEnz-EBI ]   3.6.3.4 [ BRENDA ]   3.6.3.4 [ KEGG ]   3.6.3.4 [ WIT ]
GO	nucleotide binding [Amigo]  nucleotide binding
GO	magnesium ion binding [Amigo]  magnesium ion binding
GO	copper-exporting ATPase activity [Amigo]  copper-exporting ATPase activity
GO	copper-exporting ATPase activity [Amigo]  copper-exporting ATPase activity
GO	copper-exporting ATPase activity [Amigo]  copper-exporting ATPase activity
GO	copper ion transmembrane transporter activity [Amigo]  copper ion transmembrane transporter activity
GO	copper ion binding [Amigo]  copper ion binding
GO	copper ion binding [Amigo]  copper ion binding
GO	protein binding [Amigo]  protein binding
GO	ATP binding [Amigo]  ATP binding
GO	ATP binding [Amigo]  ATP binding
GO	cytoplasm [Amigo]  cytoplasm
GO	mitochondrion [Amigo]  mitochondrion
GO	late endosome [Amigo]  late endosome
GO	Golgi apparatus [Amigo]  Golgi apparatus
GO	trans-Golgi network [Amigo]  trans-Golgi network
GO	integral to plasma membrane [Amigo]  integral to plasma membrane
GO	transport [Amigo]  transport
GO	ion transport [Amigo]  ion transport
GO	copper ion transport [Amigo]  copper ion transport
GO	cellular copper ion homeostasis [Amigo]  cellular copper ion homeostasis
GO	metabolic process [Amigo]  metabolic process
GO	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism [Amigo]  ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism
GO	copper ion import [Amigo]  copper ion import
GO	membrane [Amigo]  membrane
GO	integral to membrane [Amigo]  integral to membrane
GO	cytoplasmic membrane-bounded vesicle [Amigo]  cytoplasmic membrane-bounded vesicle
GO	basolateral plasma membrane [Amigo]  basolateral plasma membrane
GO	hydrolase activity [Amigo]  hydrolase activity
GO	hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances [Amigo]  hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
GO	metal ion transport [Amigo]  metal ion transport
GO	response to copper ion [Amigo]  response to copper ion
GO	metal ion binding [Amigo]  metal ion binding
GO	metal ion transmembrane transporter activity [Amigo]  metal ion transmembrane transporter activity
GO	perinuclear region of cytoplasm [Amigo]  perinuclear region of cytoplasm
GO	sequestering of calcium ion [Amigo]  sequestering of calcium ion
PubGene	ATP7B
TreeFam	ATP7B
CTD	540 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	ATP7B Related clones (RZPD - Berlin)
	PubMed
PubMed	132 Pubmed reference(s) in Entrez

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Sat Oct 18 14:31:41 2008